Delivery of a sebum modulator by an engineered skin microbe in mice

Knödlseder, Nastassia; Fábrega, María José; Santos Moreno, Javier; Manils, Joan; Toloza, Lorena; Marín Vilar, Maria; Fernández Avilés, Cristina; Broadbent, Katrina; Maruotti, Julien; Lemenager, Hélène; Carolis, Carlo; Zouboulis, Christos C.; Soler Prat, Concepció; Lood, Rolf; Brüggemann, Holger; Güell Cargol, Marc, 1982-

doi:http://dx.doi.org/10.1038/s41587-023-02072-4

Delivery of a sebum modulator by an engineered skin microbe in mice

Citation

Knödlseder N, Fábrega MJ, Santos-Moreno J, Manils J, Toloza L, Marín Vilar M, et al. Delivery of a sebum modulator by an engineered skin microbe in mice. Nat Biotechnol. 2024 Nov;42(11):1661-6. DOI: 10.1038/s41587-023-02072-4

Abstract

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.