Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta
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- dc.contributor.author Vilahur Chiaraviglio, Nadia, 1982-ca
- dc.contributor.author Bustamante Pineda, Marionaca
- dc.contributor.author Morales, Evaca
- dc.contributor.author Motta, Valeriaca
- dc.contributor.author Fernandez, Mariana F.ca
- dc.contributor.author Salas, Lucas A.ca
- dc.contributor.author Escaramís, Geòrgiaca
- dc.contributor.author Ballester Díez, Ferranca
- dc.contributor.author Murcia, Marioca
- dc.contributor.author Tardón, Adoninaca
- dc.contributor.author Riaño, Isolinaca
- dc.contributor.author Santa Marina, Loretoca
- dc.contributor.author Ibarluzea, Jesúsca
- dc.contributor.author Arrebola, Juan Pedroca
- dc.contributor.author Estivill, Xavier, 1955-ca
- dc.contributor.author Bollati, Valentinaca
- dc.contributor.author Sunyer Deu, Jordica
- dc.contributor.author Olea, Nicolásca
- dc.date.accessioned 2016-05-23T15:39:20Z
- dc.date.available 2017-02-01T03:00:04Z
- dc.date.issued 2016
- dc.description.abstract BACKGROUND: In utero exposure to xenostrogens may modify the epigenome. We explored the association of prenatal exposure to mixtures of xenoestrogens and genome-wide placental DNA methylation. MATERIALS & METHODS: Sex-specific associations between methylation changes in placental DNA by doubling the concentration of TEXB-alpha exposure were evaluated by robust multiple linear regression. Two CpG sites were selected for validation and replication in additional male born placentas. RESULTS: No significant associations were found, although the top significant CpGs in boys were located in the LRPAP1, HAGH, PPARGC1B, KCNQ1 and KCNQ1DN genes, previously associated to birth weight, Type 2 diabetes, obesity or steroid hormone signaling. Neither technical validation nor biological replication of the results was found in boys for LRPAP and PPARGC1B. CONCLUSION: Some suggestive genes were differentially methylated in boys in relation to prenatal xenoestrogen exposure, but our initial findings could not be validated or replicated.ca
- dc.description.sponsorship This work was part of the European-wide project Transportation Air pollution and Physical ActivitieS (TAPAS): an integrated health risk assessment program of climate change and urban policies, which had partners in Barcelona, Basel, Copenhagen, Paris, Prague, and Warsaw. TAPAS was a 4-year project funded by the Coca-Cola Foundation, AGAUR, and CREAL (http://www.tapas-program.org/). CREAL is part of CIBERESP (http://www.ciberesp.es/), the Spanish Network for Epidemiology and Public Health Research. CREAL and its members are based at and supported by the Universitat Pompeu Fabra (http://www.upf.edu/en/).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Vilahur N, Bustamante M, Morales E, Motta V, Fernandez MF, Salas LA et al. Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta. Epigenomics. 2016; 8(1): 43-54. DOI 10.2217/epi.15.91ca
- dc.identifier.doi http://dx.doi.org/10.2217/epi.15.91
- dc.identifier.issn 1750-1911
- dc.identifier.uri http://hdl.handle.net/10230/26427
- dc.language.iso engca
- dc.publisher Future Medicineca
- dc.relation.ispartof Epigenomics. 2016; 8(1): 43-54
- dc.rights © Future Medicine http://dx.doi.org/10.2217/epi.15.91ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword DNA methylation
- dc.subject.keyword TEXB
- dc.subject.keyword Endocrine disruptors
- dc.subject.keyword Epigenome xenoestrogens
- dc.subject.keyword Placenta
- dc.subject.keyword Prenatal
- dc.subject.keyword Programming
- dc.subject.other ADNca
- dc.subject.other Placentaca
- dc.title Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placentaca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca