Determinants and functions of CAFs secretome during cancer progression and therapy
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- dc.contributor.author Linares Aceituno, Jenniffer Lissethe
- dc.contributor.author Marín Jiménez, Juan A.
- dc.contributor.author Badia-Ramentol, Jordi
- dc.contributor.author Calon, Alexandre
- dc.date.accessioned 2021-06-15T06:56:44Z
- dc.date.available 2021-06-15T06:56:44Z
- dc.date.issued 2021
- dc.description.abstract Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.
- dc.format.mimetype application/pdf
- dc.identifier.citation Linares J, Marín-Jiménez JA, Badia-Ramentol J, Calon A. Determinants and functions of CAFs secretome during cancer progression and therapy. Front Cell Dev Biol. 2021;8:621070. DOI: 10.3389/fcell.2020.621070
- dc.identifier.doi http://dx.doi.org/10.3389/fcell.2020.621070
- dc.identifier.issn 2296-634X
- dc.identifier.uri http://hdl.handle.net/10230/47877
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Cell Dev Biol. 2021;8:621070
- dc.rights © 2021 Linares, Marín-Jiménez, Badia-Ramentol and Calon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Cancer-associated fibroblast (CAF)
- dc.subject.keyword Growth factors
- dc.subject.keyword Metastasis
- dc.subject.keyword Secreted factors
- dc.subject.keyword Secretome
- dc.subject.keyword Therapy
- dc.subject.keyword Tumor microenvironment (TME)
- dc.title Determinants and functions of CAFs secretome during cancer progression and therapy
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion