Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans

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• dc.contributor.author Castro, Pablo
• dc.contributor.author Luppi, Andrea
• dc.contributor.author Tagliazucchi, Enzo
• dc.contributor.author Sanz Perl, Yonatan
• dc.contributor.author Naci, Lorina
• dc.contributor.author Owen, Adrian M.
• dc.contributor.author Sitt, Jacobo D.
• dc.contributor.author Destexhe, Alain
• dc.contributor.author Cofré, Rodrigo
• dc.date.accessioned 2025-05-21T05:57:39Z
• dc.date.available 2025-05-21T05:57:39Z
• dc.date.issued 2024
• dc.description.abstract Resting-state functional magnetic resonance imaging evolves through a repertoire of functional connectivity patterns which might reflect ongoing cognition, as well as the contents of conscious awareness. We investigated whether the dynamic exploration of these states can provide robust and generalizable markers for the state of consciousness in human participants, across loss of consciousness induced by general anaesthesia or slow wave sleep. By clustering transient states of functional connectivity, we demonstrated that brain activity during unconsciousness is dominated by a recurrent pattern primarily mediated by structural connectivity and with a reduced capacity to transition to other patterns. Our results provide evidence supporting the pronounced differences between conscious and unconscious brain states in terms of whole-brain dynamics; in particular, the maintenance of rich brain dynamics measured by entropy is a critical aspect of conscious awareness. Collectively, our results may have significant implications for our understanding of consciousness and the neural basis of human awareness, as well as for the discovery of robust signatures of consciousness that are generalizable among different brain conditions.
• dc.description.sponsorship A.D. and R.C. acknowledge the support of the European Union (Human Brain Project, H2020-945539). E.T. is supported by PICT2019–02294 (Agencia I+D+i, Argentina), PIP 1122021010 (CONICET, Argentina) and ANID/FONDECYT Regular 1220995 (Chile). A.I.L. acknowledges the support of the Natural Sciences and Engineering Research Council of Canada (NSERC), [funding reference number 202209BPF-489453-401636, Banting Postdoctoral Fellowship] and FRQNT Strategic Clusters Program (2020-RS4-265502—Centre UNIQUE—Union Neuroscience and Artificial Intelligence—Quebec) via the UNIQUE Neuro-AI Excellence Award. J.D.S. acknowledges the support of the EU ERA PerMed Joint Translational 2019 project (project PerBrain). And by the JTC-HBP project MODELDxConsciousness.
• dc.format.mimetype application/pdf
• dc.identifier.citation Castro P, Luppi A, Tagliazucchi E, Perl YS, Naci L, Owen AM, et al. Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans. Commun Biol. 2024;7:1224. DOI: 10.1038/s42003-024-06858-3
• dc.identifier.doi http://dx.doi.org/10.1038/s42003-024-06858-3
• dc.identifier.issn 2399-3642
• dc.identifier.uri http://hdl.handle.net/10230/70445
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Communications Biology. 2024;7:1224
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/265502
• dc.rights © The Author(s) 2024. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Neurociència computacional
• dc.subject.other Consciència
• dc.title Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion