A novel role for lncRNAs in cell cycle control during stress adaptation
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- dc.contributor.author Solé, Carmeca
- dc.contributor.author Nadal Ribelles, Mariona, 1984-ca
- dc.contributor.author Nadal Clanchet, Eulàlia deca
- dc.contributor.author Posas Garriga, Francescca
- dc.date.accessioned 2015-06-04T06:56:50Z
- dc.date.available 2015-06-04T06:56:50Z
- dc.date.issued 2015ca
- dc.description.abstract Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression in response to environmental changes. In response to extracellular insults, stress-activated protein kinases (SAPKs) modulate cell-cycle progression and gene expression. In yeast, osmostress induces activation of the p38-related SAPK Hog1, which plays a key role in reprogramming gene expression upon osmostress. Genomic analysis has revealed the existence of a large number of long non-coding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Upon osmostress, hundreds of lncRNAs are induced by the SAPK p38/Hog1. One gene that expresses Hog1-dependent lncRNA in an antisense orientation is the CDC28 gene, which encodes CDK1 kinase that controls the cell cycle in yeast. Cdc28 lncRNA mediates the induction of CDC28 expression and this increase in the level of Cdc28 results in more efficient re-entry of the cells into the cell cycle after stress. Thus, the control of lncRNA expression as a new mechanism for the regulation of cell-cycle progression opens new avenues to understand how stress adaptation can be accomplished in response to changing environments.en
- dc.description.sponsorship The laboratory of FP and EN is supported by grants from the Spanish Government (BFU2012-33503 and FEDER to FP, BFU2011-26722 to EN), an ERC Advanced Grant Number 294294 from the EU seventh framework program (SYNCOM) and the Fundación Marcelino Botín (FMB) to FP. FP and EN are recipients of an ICREA Acadèmia (Generalitat de Catalunya). The authors declare no competing financial interesten
- dc.format.mimetype application/pdfca
- dc.identifier.citation Solé C, Nadal-Ribelles M, De Nadal E, Posas F. A novel role for lncRNAs in cell cycle control during stress adaptation. Current Genetics. 2015;61(3):299-308. DOI: 10.1007/s00294-014-0453-yca
- dc.identifier.doi http://dx.doi.org/10.1007/s00294-014-0453-y
- dc.identifier.issn 0172-8083ca
- dc.identifier.uri http://hdl.handle.net/10230/23726
- dc.language.iso engca
- dc.publisher Springerca
- dc.relation.ispartof Current Genetics. 2015;61(3):299-308
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294294
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-33503
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26722
- dc.rights © The Author(s) 2014. This article is published with open access at Springerlink.comca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword SAPKsen
- dc.subject.keyword Hog1en
- dc.subject.keyword Osmostressen
- dc.subject.keyword LncRNAen
- dc.subject.keyword Gene expressionen
- dc.subject.keyword Cell cycleen
- dc.subject.other RNAca
- dc.title A novel role for lncRNAs in cell cycle control during stress adaptationen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca