Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO.
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- dc.contributor.author Pavelka, Karelca
- dc.contributor.author Bruyère, Olivierca
- dc.contributor.author Cooper, Cyrusca
- dc.contributor.author Kanis, John A.ca
- dc.contributor.author Leeb, Burkhard F.ca
- dc.contributor.author Maheu, Emmanuelca
- dc.contributor.author Martel-Pelletier, Johanneca
- dc.contributor.author Monfort, Jordica
- dc.contributor.author Pelletier, Jean-Pierreca
- dc.contributor.author Rizzoli, Renéca
- dc.contributor.author Reginster, Jean-Yvesca
- dc.date.accessioned 2016-04-18T10:25:42Z
- dc.date.available 2016-04-18T10:25:42Z
- dc.date.issued 2016
- dc.description.abstract Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit-risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated.ca
- dc.description.sponsorship This meeting was founded by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, a Belgian not-for-profit organisation.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Pavelka K, Bruyère O, Cooper C, Kanis JA, Leeb BF, Maheu E et al. Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. Drugs Aging. 2016 Feb;33(2):75-85. doi: 10.1007/s40266-016-0347-4.ca
- dc.identifier.doi http://dx.doi.org/10.1007/s40266-016-0347-4
- dc.identifier.issn 1170-229X
- dc.identifier.uri http://hdl.handle.net/10230/26105
- dc.language.iso engca
- dc.publisher Adisca
- dc.relation.ispartof Drugs Aging. 2016 Feb;33(2):75-85
- dc.rights The Pavelka K, Bruyère O, Cooper C, Kanis JA, Leeb BF, Maheu E et al. Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. Drugs Aging. 2016 Feb;33(2):75-85. doi: 10.1007/s40266-016-0347-4.) 2016. This article is published with open access at Springerlink.comca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Artritis -- Tractamentca
- dc.title Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca