Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts

Lubczyńska, Małgorzata Joanna, 1984-; Sunyer Deu, Jordi; Tiemeier, Henning; Porta, Daniela; Kasper-Sonnenberg, Monika; Jaddoe, Vincent W. V.; Basagaña Flores, Xavier; Dalmau Bueno, Albert; Forastiere, Francesco; Wittsiepe, Jürgen; Hoffmann, Barbara; Nieuwenhuijsen, Mark J.; Hoek, Gerard; de Hoogh, Kees; Brunekreef, Bert; Guxens Junyent, Mònica

Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts

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dc.contributor.author Lubczyńska, Małgorzata Joanna, 1984-ca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Tiemeier, Henningca
dc.contributor.author Porta, Danielaca
dc.contributor.author Kasper-Sonnenberg, Monikaca
dc.contributor.author Jaddoe, Vincent W. V.ca
dc.contributor.author Basagaña Flores, Xavierca
dc.contributor.author Dalmau Bueno, Albertca
dc.contributor.author Forastiere, Francescoca
dc.contributor.author Wittsiepe, Jürgenca
dc.contributor.author Hoffmann, Barbaraca
dc.contributor.author Nieuwenhuijsen, Mark J.ca
dc.contributor.author Hoek, Gerardca
dc.contributor.author de Hoogh, Keesca
dc.contributor.author Brunekreef, Bertca
dc.contributor.author Guxens Junyent, Mònicaca
dc.date.accessioned 2018-06-05T09:00:41Z
dc.date.issued 2017
dc.description.abstract BACKGROUND: Little is known about developmental neurotoxicity of particulate matter composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood. METHODS: We analyzed data from 4 European population-based birth cohorts in the Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to predict concentrations at participants' residential addresses at birth. We selected 8 elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc) and used principal component analysis to combine elements from the same sources. Cognitive (general, verbal, and non-verbal) and psychomotor (fine and gross) functions were assessed between 1 and 9years of age. Adjusted cohort-specific effect estimates were combined using random-effects meta-analysis. RESULTS: 7246 children were included in this analysis. Single element analysis resulted in negative association between estimated airborne iron and fine motor function (-1.25 points [95% CI -2.45 to -0.06] per 100ng/m3 increase of iron). Association between the motorized traffic component, derived from principal component analysis, and fine motor function was not significant (-0.29 points [95% CI -0.64 to 0.06] per unit increase). None of the elements were associated with gross motor function or cognitive function, although the latter estimates were predominantly negative. CONCLUSION: Our results suggest that iron, a highly prevalent element in motorized traffic pollution, may be a neurotoxic compound. This raises concern given the ubiquity of motorized traffic air pollution.
dc.description.sponsorship This work was supported by the European Community's Seventh Framework Program (FP7/ 2007–2011), grant agreements 211250 and 243406. The European Union's Horizon 2020 Research and Innovation Program (no.: 633595, DynaHealth) and also received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement no. 733206 (LifeCycle). Also by the EU Commission (261357).
dc.format.mimetype application/pdf
dc.identifier.citation Lubczyńska MJ, Sunyer J, Tiemeier H, Porta D, Kasper-Sonnenberg M, Jaddoe VWV et al. Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohorts. Environ Int. 2017 Dec;109:170-80. DOI: 10.1016/j.envint.2017.09.015
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2017.09.015
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/34827
dc.language.iso eng
dc.publisher Elsevierca
dc.relation.ispartof Environment International. 2017 Dec;109:170-80
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/243406
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633595
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Aire -- Contaminació
dc.subject.other Trastorns de la cognició
dc.subject.other Tests neuropsicològics
dc.subject.other Infants -- Salut i higiene
dc.subject.other Infants -- Desenvolupament
dc.title Exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor function in childhood in four European birth cohortsca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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