Dealing with transcriptional outbursts during S phase to protect genomic integrity

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• dc.contributor.author Duch, Albaca
• dc.contributor.author Nadal Clanchet, Eulàlia deca
• dc.contributor.author Posas Garriga, Francescca
• dc.date.accessioned 2015-11-30T17:57:31Z
• dc.date.available 2015-11-30T17:57:31Z
• dc.date.issued 2013
• dc.description.abstract Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes compatible under normal growth conditions. When conflict management fails, the head-on encounter between RNA and DNA polymerases results in genomic instability unless conflict resolution mechanisms are activated. Nevertheless, there are specific situations in which cells need to dramatically change their transcriptional landscape to adapt to environmental challenges. Signal transduction pathways, such as stress-activated protein kinases (SAPKs), serve to regulate gene expression in response to environmental insults. Prototypical members of SAPKs are the yeast Hog1 and mammalian p38. In response to stress, p38/Hog1 SAPKs control transcription and also regulate cell cycle progression. When yeast cells are stressed during S phase, Hog1 promotes gene induction and, remarkably, also delays replication by directly affecting early origin firing and fork progression. Therefore, by delaying replication, Hog1 plays a key role in preventing conflicts between RNA and DNA polymerases. In this review, we focus on the genomic determinants and mechanisms that make compatible transcription with replication during S phase to prevent genomic instability, especially in response to environmental changes.ca
• dc.description.sponsorship The laboratory of F.P. and E.N. is supported by grants from the Spanish Government (BFU2012-33503 and FEDER to F.P.; BFU2011-26722 to E.N.), the Consolider Ingenio 2010 program CSD2007-0015 and the Fundación Marcelino Botín to F.P. F.P. and E.N. are recipients of an Institució Catalana de Recerca i Estudis Avançats Acadèmia (Generalitat de Catalunya).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Duch A, de Nadal E, Posas F et al. Dealing with transcriptional outbursts during S phase to protect genomic integrity. Journal of molecular biology. 2013;425(23):4745-55. DOI: 10.1016/j.jmb.2013.08.019ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.jmb.2013.08.019
• dc.identifier.issn 0022-2836
• dc.identifier.uri http://hdl.handle.net/10230/25272
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Journal of molecular biology. 2013;425(23):4745-55
• dc.rights © 2013. Published by Elsevier Ltd. Open access under CC BY-NC-ND license.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ca
• dc.subject.keyword Transcriptionen
• dc.subject.keyword Stress responsesen
• dc.subject.keyword Replicationen
• dc.subject.keyword Cell cycle regulationen
• dc.subject.other ADNca
• dc.subject.other Saccharomyces cerevisiae -- Metabolismeca
• dc.subject.other Transcripció genèticaca
• dc.title Dealing with transcriptional outbursts during S phase to protect genomic integrityca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca