Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study

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• dc.contributor.author Kocatürk, Emek
• dc.contributor.author Giménez Arnau, Anna Maria
• dc.contributor.author Maurer, Marcus
• dc.date.accessioned 2021-08-27T08:13:43Z
• dc.date.issued 2021
• dc.description.abstract Background: Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown. Aim: To analyze the course and features of CU during and after pregnancy. Patients and methods: PREG-CU is an international, multicenter study of the Urticaria Centers of Reference and Excellence (UCARE) network. Data were collected via a 47-item questionnaire completed by CU patients, who became pregnant within the last 3 years. Results: A total of 288 pregnancies of 288 CU patients from 13 countries were analyzed (mean age at pregnancy: 32.1 ± 6.1 years, duration of CU: 84.9 ± 74.5 months; CSU 66.9%, CSU + CIndU 20.3%, CIndU 12.8%).During pregnancy, 51.1% of patients rated their CU as improved, 28.9% as worse, and 20.0% as unchanged.CU exacerbations most commonly occurred exclusively during the third trimester (in 34 of 124 patients; 27.6%) or the first (28 of 124; 22.8%). The risk factors for worsening of CU during pregnancy were having mild disease and no angioedema before pregnancy, not taking treatment before pregnancy, CIndU, CU worsening during a previous pregnancy, treatment during pregnancy, and stress as a driver of exacerbations. After giving birth, urticaria disease activity remained unchanged in 43.8% of CU patients, whereas 37.4% and 18.1% experienced worsening and improvement, respectively. Conclusions: These results demonstrate the complex impact of pregnancy on the course of CU and help to better counsel patients who want to become pregnant and to manage CU during pregnancy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kocatürk E, Al-Ahmad M, Krause K, Gimenez-Arnau AM, Thomsen SF, Conlon N, et al. Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study. Allergy. 2021;76(10):3133-44. DOI: 10.1111/all.14950
• dc.identifier.doi http://dx.doi.org/10.1111/all.14950
• dc.identifier.issn 0105-4538
• dc.identifier.uri http://hdl.handle.net/10230/48339
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Allergy. 2021;76(10):3133-44
• dc.rights This is the peer reviewed version of the following article: Kocatürk E, Al-Ahmad M, Krause K, Gimenez-Arnau AM, Thomsen SF, Conlon N, et al. Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study. Allergy. 2021;76(10):3133-44. DOI: 10.1111/all.14950, which has been published in final form at http://dx.doi.org/10.1111/all.14950. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Breastfeeding
• dc.subject.keyword Disease activity
• dc.subject.keyword Hormones
• dc.subject.keyword Pregnancy
• dc.subject.keyword Urticaria
• dc.title Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion