Ambient air pollution and adult asthma incidence in six european cohorts (Escape)
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- dc.contributor.author Jacquemin Leonard, Bénédicteca
- dc.contributor.author Carsin, Anne-Elieca
- dc.contributor.author Cirach, Martaca
- dc.contributor.author De Nazelle, Audreyca
- dc.contributor.author Nieuwenhuijsen, Mark J.ca
- dc.contributor.author Sunyer Deu, Jordica
- dc.contributor.author Kauffmann, Francineca
- dc.date.accessioned 2016-04-26T14:18:24Z
- dc.date.available 2016-04-26T14:18:24Z
- dc.date.issued 2015
- dc.description.abstract BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.ca
- dc.description.sponsorship The research leading to these results was funded by the European Community’s Seventh Framework Program (FP7/2007-2011) under grant agreement no. 211250.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M et al. Ambient air pollution and adult asthma incidence in six european cohorts (Escape). Environmental health perspectives. 2015; 123(6): 613-621. DOI 10.1289/ehp.1408206ca
- dc.identifier.doi http://dx.doi.org/10.1289/ehp.1408206
- dc.identifier.issn 0091-6765
- dc.identifier.uri http://hdl.handle.net/10230/26175
- dc.language.iso engca
- dc.publisher National Institute of Environmental Health Sciencesca
- dc.relation.ispartof Environmental health perspectives. 2015; 123(6): 613-621
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
- dc.rights Reproduced with permission from Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1408206ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Asma -- Epidemiologiaca
- dc.subject.other Òxids de nitrogen -- Aspectes ambientalsca
- dc.title Ambient air pollution and adult asthma incidence in six european cohorts (Escape)ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca