Avances en la valoración de la salud ósea en el trasplantado renal
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- dc.contributor.author Pérez-Sáez, María Joséca
- dc.contributor.author Prieto-Alhambra, Danielca
- dc.contributor.author Díez Pérez, Adolfoca
- dc.contributor.author Pascual Santos, Julioca
- dc.date.accessioned 2018-07-04T07:46:33Z
- dc.date.available 2018-07-04T07:46:33Z
- dc.date.issued 2017
- dc.description.abstract Bone disease related to chronic kidney disease and, particularly, to kidney transplant patients is a common cause or morbidity and mortality, especially due to a higher risk of osteoporotic fractures. Despite the fact that this has been known for decades, to date, an appropriate diagnostic strategy has yet to be established. Apart from bone biopsy, which is invasive and scarcely used, no other technique is available to accurately establish the risk of fracture in kidney patients. Techniques applied to the general population, such as bone densitometry, have not been subjected to sufficient external validation and their use is not systematic. This means that the identification of patients at risk of fracture and therefore those who are candidates for preventive strategies is an unmet need. Bone strength, defined as the ability of the bone to resist fracture, is determined by bone mineral density (measured by bone densitometry), trabecular architecture and bone tissue quality. The trabecular bone score estimates bone microarchitecture, and low values have been described as an independent predictor of increased fracture risk. Bone microindentation is a minimally invasive technique that measures resistance of the bone to micro-cracks (microscopic separation of mineralised collagen fibres), and therefore bone tissue biomechanical properties. The superiority over bone densitometry of the correlation between the parameters measured by trabecular bone score and microindentation with the risk of fracture in diverse populations led us to test its feasibility in chronic kidney disease and kidney transplant patients.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pérez-Sáez MJ, Prieto-Alhambra D, Díez-Pérez A, Pascual J. Avances en la valoración de la salud ósea en el trasplantado renal. Nefrologia. 2018 Jan - Feb;38(1):27-33. DOI: 10.1016/j.nefro.2017.04.002
- dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2017.04.002
- dc.identifier.issn 0211-6995
- dc.identifier.uri http://hdl.handle.net/10230/35025
- dc.language.iso spa
- dc.publisher Elsevierca
- dc.relation.ispartof Nefrologia. 2018 Jan - Feb;38(1):27-33
- dc.rights © 2017 Sociedad Española de Nefrología. Publicado por Elsevier España. S.L.U. Este es un artículo Open Access bajo la licencia CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0
- dc.subject.keyword Bone microindentation
- dc.subject.keyword Bone mineral disease
- dc.subject.keyword Bone strength
- dc.subject.keyword Enfermedad mineral ósea
- dc.subject.keyword Fracturas
- dc.subject.keyword Fractures
- dc.subject.keyword Kidney transplant
- dc.subject.keyword Microindentación ósea
- dc.subject.keyword Resistencia ósea
- dc.subject.keyword Score trabecular óseo
- dc.subject.keyword Trabecular bone score
- dc.subject.keyword Trasplante renal
- dc.subject.other Ronyons--Trasplantació
- dc.subject.other Ossos -- Malalties
- dc.subject.other Fractures
- dc.subject.other
- dc.title Avances en la valoración de la salud ósea en el trasplantado renalca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion