Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder

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• dc.contributor.author Domènech Salgado, Laura, 1989-
• dc.contributor.author Willis, Jesse R.
• dc.contributor.author Alemany-Navarro, María
• dc.contributor.author Morell, Marta
• dc.contributor.author Real, Eva
• dc.contributor.author Escaramís, Geòrgia
• dc.contributor.author Bertolín, Sara
• dc.contributor.author Sánchez Chinchilla, Daniel
• dc.contributor.author Balcells, Susana
• dc.contributor.author Segalàs, Cinto
• dc.contributor.author Estivill, Xavier, 1955-
• dc.contributor.author Menchón, José M.
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
• dc.contributor.author Alonso, Pino
• dc.contributor.author Rabionet, Raquel
• dc.date.accessioned 2022-04-20T06:30:27Z
• dc.date.available 2022-04-20T06:30:27Z
• dc.date.issued 2022
• dc.description.abstract Although the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have reported associations between changes in gut microbiota and neuropsychiatric disorders, including depression or autism. Furthermore, a pediatric-onset neuropsychiatric OCD-related syndrome occurs after streptococcal infection, which might indicate that exposure to certain microbes could be involved in OCD susceptibility. However, only one study has investigated the microbiome of OCD patients to date. We performed 16S ribosomal RNA gene-based metagenomic sequencing to analyze the stool and oropharyngeal microbiome composition of 32 OCD cases and 32 age and gender matched controls. We estimated different α- and β-diversity measures and performed LEfSe and Wilcoxon tests to assess differences in bacterial distribution. OCD stool samples showed a trend towards lower bacterial α-diversity, as well as an increase of the relative abundance of Rikenellaceae, particularly of the genus Alistipes, and lower relative abundance of Prevotellaceae, and two genera within the Lachnospiraceae: Agathobacer and Coprococcus. However, we did not observe a different Bacteroidetes to Firmicutes ratio between OCD cases and controls. Analysis of the oropharyngeal microbiome composition showed a lower Fusobacteria to Actinobacteria ratio in OCD cases. In conclusion, we observed an imbalance in the gut and oropharyngeal microbiomes of OCD cases, including, in stool, an increase of bacteria from the Rikenellaceae family, associated with gut inflammation, and a decrease of bacteria from the Coprococcus genus, associated with DOPAC synthesis.
• dc.description.sponsorship This project was supported by grants from the Spanish ministry of science and innovation (MICINN; SAF2013-49108-R); the Carlos III Health Institute (PI16/00950, PI18/00856, PI19/01184); FEDER funds (‘A way to build Europe’) and by the Agency of University and Research Funding Management of the Catalan Government (2014 SGR 1672 and 2017 SGR 738). We thank CERCA Programme / Generalitat de Catalunya for institutional support. LD was supported by a Severo Ochoa grant (SVP-2013-068066), MA was supported by the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia Grant co-funded by the European Social Fund (ESF) “ESF, Investing in your future” (2017 FI_B 00327), DSC was supported by a grant from the MICINN (BES-2014-069814) and RR was supported by a fellowship from the Health Department of the Generalitat de Catalunya through the PERIS 2016-2020 program (SLT002/16/00310).
• dc.format.mimetype application/pdf
• dc.identifier.citation Domènech L, Willis J, Alemany-Navarro M, Morell M, Real E, Escaramís G, Bertolín S, Sánchez Chinchilla D, Balcells S, Segalàs C, Estivill X, Menchón JM, Gabaldón T, Alonso P, Rabionet R. Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder. Sci Rep. 2022 Jan 27;12(1):1448. DOI: 10.1038/s41598-022-05480-9
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-022-05480-9
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/52854
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Sci Rep. 2022 Jan 27;12(1):1448
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49108-R
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biomarkers
• dc.subject.keyword Obsessive compulsive disorder
• dc.title Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion