ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
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- dc.contributor.author Poliński, Patryk
- dc.contributor.author Miret-Cuesta, Marta
- dc.contributor.author Irimia Martínez, Manuel
- dc.date.accessioned 2025-07-23T07:11:38Z
- dc.date.available 2025-07-23T07:11:38Z
- dc.date.issued 2025
- dc.description Data de publicació electrònica: 09-06-2025
- dc.description.abstract Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.
- dc.description.sponsorship The research has been funded by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (ERCCoG-LS2-101002275 to M.I.), Spanish Ministry of Science and Innovation (PID2020-115040GB-I00 to M.I.), the European Union's Horizon 2020 research and innovation program under grant agreements No. 721890 to P.P.
- dc.format.mimetype application/pdf
- dc.identifier.citation Poliński P, Cuesta MM, Irimia M. ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay. Cytoskeleton (Hoboken). 2025 Jun 9. DOI: 10.1002/cm.22051
- dc.identifier.doi http://dx.doi.org/10.1002/cm.22051
- dc.identifier.issn 1949-3584
- dc.identifier.uri http://hdl.handle.net/10230/70977
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Cytoskeleton (Hoboken). 2025 Jun 9
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101002275
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-115040GB-I00
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/721890
- dc.rights © 2025 The Author(s). Cytoskeleton published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword ARC
- dc.subject.keyword Alternative splicing
- dc.subject.keyword Formin
- dc.subject.keyword Synapse
- dc.title ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion