ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay

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dc.contributor.authorPoliński, Patryk
dc.contributor.authorMiret-Cuesta, Marta
dc.contributor.authorIrimia Martínez, Manuel
dc.date.accessioned2025-07-23T07:11:38Z
dc.date.available2025-07-23T07:11:38Z
dc.date.issued2025
dc.descriptionData de publicació electrònica: 09-06-2025
dc.description.abstractActin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.
dc.description.sponsorshipThe research has been funded by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (ERCCoG-LS2-101002275 to M.I.), Spanish Ministry of Science and Innovation (PID2020-115040GB-I00 to M.I.), the European Union's Horizon 2020 research and innovation program under grant agreements No. 721890 to P.P.
dc.format.mimetypeapplication/pdf
dc.identifier.citationPoliński P, Cuesta MM, Irimia M. ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay. Cytoskeleton (Hoboken). 2025 Jun 9. DOI: 10.1002/cm.22051
dc.identifier.doihttp://dx.doi.org/10.1002/cm.22051
dc.identifier.issn1949-3584
dc.identifier.urihttp://hdl.handle.net/10230/70977
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofCytoskeleton (Hoboken). 2025 Jun 9
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/101002275
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/PID2020-115040GB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/721890
dc.rights© 2025 The Author(s). Cytoskeleton published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keywordARC
dc.subject.keywordAlternative splicing
dc.subject.keywordFormin
dc.subject.keywordSynapse
dc.titleARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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