Cannabinoid receptor 2 participates in amyloid-β processing in a mouse model of Alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis-based medicine

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• dc.contributor.author Aso Pérez, Esterca
• dc.contributor.author Andrés Benito, Polca
• dc.contributor.author Carmona, Margaritaca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Ferrer, Isidreca
• dc.date.accessioned 2017-04-24T10:04:17Z
• dc.date.available 2017-04-24T10:04:17Z
• dc.date.issued 2016
• dc.description.abstract The endogenous cannabinoid system represents a promising therapeutic target to modify neurodegenerative pathways linked to Alzheimer's disease (AD). The aim of the present study was to evaluate the specific contribution of CB2 receptor to the progression of AD-like pathology and its role in the positive effect of a cannabis-based medicine (1:1 combination of Δ9-tetrahidrocannabinol and cannabidiol) previously demonstrated to be beneficial in the AβPP/PS1 transgenic model of the disease. A new mouse strain was generated by crossing AβPP/PS1 transgenic mice with CB2 knockout mice. Results show that lack of CB2 exacerbates cortical Aβ deposition and increases the levels of soluble Aβ40. However, CB2 receptor deficiency does not affect the viability of AβPP/PS1 mice, does not accelerate their memory impairment, does not modify tau hyperphosphorylation in dystrophic neurites associated to Aβ plaques, and does not attenuate the positive cognitive effect induced by the cannabis-based medicine in these animals. These findings suggest a minor role for the CB2 receptor in the therapeutic effect of the cannabis-based medicine in AβPP/PS1 mice, but also constitute evidence of a link between CB2 receptor and Aβ processing.
• dc.description.sponsorship The authors’ work is supported by CIBERNED (Institute of Health Carlos III, Spanish Ministry of Economy and Competitiveness)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Aso E, Andrés-Benito P, Carmona M, Maldonado R, Ferrer I. Cannabinoid receptor 2 rarticipates in amyloid-β processing in a mouse model of alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis-based medicine. J Alzheimers Dis. 2016;51(2):489-500. DOI: 10.3233/JAD-150913
• dc.identifier.doi http://dx.doi.org/10.3233/JAD-150913
• dc.identifier.issn 1387-2877
• dc.identifier.uri http://hdl.handle.net/10230/30875
• dc.language.iso eng
• dc.publisher IOS Pressca
• dc.relation.ispartof Journal of Alzheimer's Disease. 2016;51(2):489-500
• dc.rights The final publication is available at IOS Press through http://dx.doi.org/10.3233/JAD-150913
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Alzheimer, Malaltia d'
• dc.subject.other Cannabinoides -- Receptors
• dc.subject.other Cannabis
• dc.title Cannabinoid receptor 2 participates in amyloid-β processing in a mouse model of Alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis-based medicineca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion