Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Arancibia-Riveros, Camila
• dc.contributor.author Tresserra-Rimbau, Anna
• dc.contributor.author Castro-Barquero, Sara
• dc.contributor.author Casas, Rosa
• dc.contributor.author Vázquez-Ruiz, Zenaida
• dc.contributor.author Ros, Emilio
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Estruch, Ramón
• dc.contributor.author López-Sabater, M. Carmen
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.date.accessioned 2023-04-05T06:15:48Z
• dc.date.available 2023-04-05T06:15:48Z
• dc.date.issued 2022
• dc.description.abstract Desaturase enzyme activities (DEA) are associated with several metabolic diseases. The aim of the present study was to assess the relationship between estimated plasma DEA and the metabolic syndrome (MetS), as well as their relationship with individual components of the MetS. We conducted a longitudinal study of 148 participants recruited at random from the PREDIMED trial (Hospital Clinic site). At baseline and after 1 year of follow-up, DEA were estimated from product/precursor ratios of individual plasma fatty acids. Logistic regressions were used to assess the relationship of estimated DEA MetS, adjusted for potential cofounders. Estimated Δ5 desaturase (D5D) activity was associated with lower risk of MetS, whereas stearoyl-CoA (SCD)-16 and SCD-18 were negatively associated with MetS status. SCD-16, SCD-18, and Δ6 desaturase (D6D) were positively associated with triglycerides, SCD-18 was inversely associated with HDL-cholesterol. Estimated D6D activity was found to be associated with increases in diastolic blood pressure. In contrast, D5D was negatively associated with triglycerides, diastolic blood pressure and waist circumference. The present longitudinal study suggests that estimated SCD-16, SCD-18, and D6D have a negative impact in MetS and its components, whereas D5D may have beneficial effects for metabolic health.
• dc.description.sponsorship This research has been supported by the CICYT [PID2020-114022RB-I00], CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE), and Generalitat de Catalunya (GC) [2017SGR 196]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Arancibia-Riveros C, Tresserra-Rimbau A, Castro-Barquero S, Casas R, Vázquez-Ruiz Z, Ros E, Fitó M, Estruch R, López-Sabater MC, Lamuela-Raventós RM. Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study. Front Nutr. 2022 Oct 26;9:991277. DOI: 10.3389/fnut.2022.991277
• dc.identifier.doi http://dx.doi.org/10.3389/fnut.2022.991277
• dc.identifier.issn 2296-861X
• dc.identifier.uri http://hdl.handle.net/10230/56408
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Nutr. 2022 Oct 26;9:991277
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
• dc.rights © 2022 Domínguez-López, Arancibia-Riveros, Tresserra-Rimbau, Castro-Barquero, Casas, Vázquez-Ruiz, Ros, Fitó, Estruch, López-Sabater and Lamuela-Raventós. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword PREDIMED
• dc.subject.keyword Desaturases
• dc.subject.keyword Fatty acids
• dc.subject.keyword Gas chromatography
• dc.subject.keyword Metabolic syndrome
• dc.title Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion