Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people

Zumel Marne, María Ángela, 1984-; Castaño Vinyals, Gemma; Alguacil Ojeda, Juan; Villanueva, Cristina M.; Maule, Milena; Gracia Lavedan, Esther; Momoli, Franco; Krewski, Daniel; Mohipp, Charmaine; Petridou, Eleni; Bouka, Evdoxia; Merletti, Franco; Migliore, Enrica; Piro, Sara; Ha, Mina; Mannetje, Andrea 't; Eng, Amanda; Aragonés, Núria; Cardis, Elisabeth

Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people

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dc.contributor.author Zumel Marne, María Ángela, 1984-
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Alguacil Ojeda, Juan
dc.contributor.author Villanueva, Cristina M.
dc.contributor.author Maule, Milena
dc.contributor.author Gracia Lavedan, Esther
dc.contributor.author Momoli, Franco
dc.contributor.author Krewski, Daniel
dc.contributor.author Mohipp, Charmaine
dc.contributor.author Petridou, Eleni
dc.contributor.author Bouka, Evdoxia
dc.contributor.author Merletti, Franco
dc.contributor.author Migliore, Enrica
dc.contributor.author Piro, Sara
dc.contributor.author Ha, Mina
dc.contributor.author Mannetje, Andrea 't
dc.contributor.author Eng, Amanda
dc.contributor.author Aragonés, Núria
dc.contributor.author Cardis, Elisabeth
dc.date.accessioned 2022-02-02T07:30:22Z
dc.date.available 2022-02-02T07:30:22Z
dc.date.issued 2021
dc.description.abstract Brain tumours (BTs) are one of the most frequent tumour types in young people. We explored the association between tap water, exposure to trihalomethanes (THM) and nitrate and neuroepithelial BT risk in young people. Analysis of tap water consumption were based on 321 cases and 919 appendicitis controls (10-24 years old) from 6 of the 14 participating countries in the international MOBI-Kids case-control study (2010-2016). Available historical residential tap water concentrations of THMs and nitrate, available from 3 countries for 86 cases and 352 controls and 85 cases and 343 for nitrate, respectively, were modelled and combined with the study subjects' personal consumption patterns to estimate ingestion and residential exposure levels in the study population (both pre- and postnatal). The mean age of participants was 16.6 years old and 56% were male. The highest levels and widest ranges for THMs were found in Spain (residential and ingested) and Italy and in Korea for nitrate. There was no association between BT and the amount of tap water consumed and the showering/bathing frequency. Odds Ratios (ORs) for BT in relation to both pre- and postnatal residential and ingestion levels of THMs were systematically below 1 (OR = 0.37 (0.08-1.73)) for postnatal average residential THMs higher than 66 μg/L. For nitrate, all ORs were above 1 (OR = 1.80 (0.91-3.55)) for postnatal average residential nitrate levels higher than 8.5 mg/L, with a suggestion of a trend of increased risk of neuroepithelial BTs with increasing residential nitrate levels in tap water, which appeared stronger in early in life. This, to our knowledge, is the first study on this topic in young people. Further research is required to clarify the observed associations.
dc.format.mimetype application/pdf
dc.identifier.citation Zumel-Marne A, Castaño-Vinyals G, Alguacil J, Villanueva CM, Maule M, Gracia-Lavedan E, Momoli F, Krewski D, Mohipp C, Petridou E, Bouka E, Merletti F, Migliore E, Piro S, Ha M, Mannetje A', Eng A, Aragones N, Cardis E. Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people. Environ Res. 2021;200:111392. DOI: 10.1016/j.envres.2021.111392
dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2021.111392
dc.identifier.issn 0013-9351
dc.identifier.uri http://hdl.handle.net/10230/52390
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Res. 2021;200:111392
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Adolescents
dc.subject.keyword Brain tumours
dc.subject.keyword Children
dc.subject.keyword Disinfection by-products
dc.subject.keyword Nitrate
dc.subject.keyword THM
dc.subject.keyword Water
dc.subject.keyword Young adults
dc.title Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

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