The transcription factor code: a beacon for histone methyltransferase docking
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- dc.contributor.author Torcal Garcia, Guillem, 1991-
- dc.contributor.author Graf, T. (Thomas)
- dc.date.accessioned 2021-07-14T07:03:45Z
- dc.date.issued 2021
- dc.description.abstract Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone methyltransferases (HMTs) to gene regulatory elements (GREs) of developmental genes is important for the correct activation and silencing of these genes, but the drivers of this recruitment are largely unknown. Here we propose that lineage-instructive transcription factors (Lin-TFs) act as general recruiters of HMT complexes to cell type-specific GREs through protein-protein interactions. We also postulate that the specificity of these interactions is dictated by Lin-TF post-translational modifications (PTMs), which act as a 'transcription factor code' that can determine the directionality of cell fate decisions during differentiation and development.
- dc.format.mimetype application/pdf
- dc.identifier.citation Torcal Garcia G, Graf T. The transcription factor code: a beacon for histone methyltransferase docking. Trends Cell Biol. 2021 Oct;31(10):792-800. DOI: 10.1016/j.tcb.2021.04.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.tcb.2021.04.001
- dc.identifier.issn 0962-8924
- dc.identifier.uri http://hdl.handle.net/10230/48177
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Trends Cell Biol. 2021 Oct;31(10):792-800
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.tcb.2021.04.001
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Gene regulation
- dc.subject.keyword Histone methylation
- dc.subject.keyword Histone methyltransferase
- dc.subject.keyword Post-translational modification
- dc.subject.keyword Transcription factor
- dc.title The transcription factor code: a beacon for histone methyltransferase docking
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion