Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients

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• dc.contributor.author González, Nerea
• dc.contributor.author Loroño, Ane
• dc.contributor.author Aguirre, Urko
• dc.contributor.author Lázaro, Santiago
• dc.contributor.author Baré, Marisa
• dc.contributor.author Redondo, Maximino
• dc.contributor.author Briones, Eduardo
• dc.contributor.author Sarasqueta, Cristina
• dc.contributor.author Bilbao, Amaia
• dc.contributor.author Fernández de Larrea-Baz, Nerea
• dc.contributor.author Quintana, José María
• dc.contributor.author REDISSEC-CARESS/CCR group
• dc.date.accessioned 2022-09-29T06:50:42Z
• dc.date.available 2022-09-29T06:50:42Z
• dc.date.issued 2021
• dc.description.abstract Background: the aim of this study was to identify predictors of mortality in elderly patients undergoing colorectal cancer surgery and to develop a risk score. Methods: this was an observational prospective cohort study. Individuals over 80 years diagnosed with colorectal cancer and treated surgically were recruited in 18 hospitals in the Spanish National Health Service, between June 2010 and December 2012, and were followed up 1, 2, 3, and 5 years after surgery. Sociodemographic and clinical data were collected. The primary outcomes were mortality at 2 and between 2 and 5 years after the index admission. Results: the predictors of mortality 2 years after surgery were haemoglobin ≤ 10 g/dl and colon locations (HR 1.02; CI 0.51-2.02), ASA class of IV (HR 3.55; CI 1.91-6.58), residual tumour classification of R2 (HR 7.82; CI 3.11-19.62), TNM stage of III (HR 2.14; CI 1.23-3.72) or IV (HR 3.21; CI 1.47-7), LODDS of more than - 0.53 (HR 3.08; CI 1.62-5.86)) and complications during admission (HR 1.73; CI 1.07-2.80). Between 2 and 5 years of follow-up, the predictors were no tests performed within the first year of follow-up (HR 2.58; CI 1.21-5.46), any complication due to the treatment within the 2 years of follow-up (HR 2.47; CI 1.27-4.81), being between 85 and 89 and not having radiotherapy within the second year of follow-up (HR 1.60; CI 1.01-2.55), no colostomy closure within the 2 years of follow-up (HR 4.93; CI 1.48-16.41), medical complications (HR 1.61; CI 1.06-2.44), tumour recurrence within the 2 years of follow-up period (HR 3.19; CI 1.96-5.18), and readmissions at 1 or 2 years of follow-up after surgery (HR 1.44; CI 0.86-2.41). Conclusion: we have identified variables that, in our sample, predict mortality 2 and between 2 and 5 years after surgery for colorectal cancer older patients. We have also created risks scores, which could support the decision-making process.
• dc.format.mimetype application/pdf
• dc.identifier.citation González N, Loroño A, Aguirre U, Lázaro S, Baré M, Redondo M, et al. Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients. J Surg Oncol. 2021 Aug 26; 19(1): 252. DOI: 10.1186/s12957-021-02356-6.
• dc.identifier.doi http://dx.doi.org/10.1186/s12957-021-02356-6
• dc.identifier.issn 1477-7819
• dc.identifier.uri http://hdl.handle.net/10230/54201
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.rights Copyright © González N, Loroño A, Aguirre U, Lázaro S, Baré M, Redondo M, 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Colorectal cancer
• dc.subject.keyword Elderly
• dc.subject.keyword Mortality
• dc.subject.keyword Outcome
• dc.subject.keyword Risk score
• dc.subject.keyword Surgery
• dc.title Risk scores to predict mortality 2 and 5 years after surgery for colorectal cancer in elderly patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion