Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech
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- dc.contributor.author He, Rui
- dc.contributor.author Al-Tamimi, Jalal
- dc.contributor.author Sánchez Benavides, Gonzalo
- dc.contributor.author Montaña Valverde, Guillermo
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author Grau-Rivera, Oriol
- dc.contributor.author Suárez-Calvet, Marc
- dc.contributor.author Minguillón, Carolina
- dc.contributor.author Fauria, Karine
- dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
- dc.contributor.author Hinzen, Wolfram
- dc.date.accessioned 2024-07-24T06:21:53Z
- dc.date.available 2024-07-24T06:21:53Z
- dc.date.issued 2024
- dc.description.abstract Abnormal deposition of Aβ amyloid is an early neuropathological marker of Alzheimer's disease (AD), arising long ahead of clinical symptoms. Non-invasive measures of associated early neurofunctional changes, together with easily accessible behavioral readouts of these changes, could be of great clinical benefit. We pursued this aim by investigating large-scale cortical gradients of functional connectivity with functional MRI, which capture the hierarchical integration of cortical functions, together with acoustic-prosodic features from spontaneous speech, in cognitively unimpaired older adults with and without Aβ positivity (total N = 188). We predicted distortions of the cortical hierarchy associated with prosodic changes in the Aβ + group. Results confirmed substantially altered cortical hierarchies and less variability in these in the Aβ + group, together with an increase in quantitative prosodic measures, which correlated with gradient variability as well as digit span test scores. Overall, these findings confirm that long before the clinical stage and objective cognitive impairment, increased risk of cognitive decline as indexed by Aβ accumulation is marked by neurofunctional changes in the cortical hierarchy, which are related to automatically extractable speech patterns and alterations in working memory functions.
- dc.description.sponsorship This research was supported by the China Scholarship Council (CSC202108390062 to RH), the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) (grant PID2019-105241 GB-I00/AEI/10.13039/501100011033 to WH), and partially by French Investissements d’Avenir - Labex EFL program (ANR-10- LABX-0083 to the IdEx Université Paris Cité - ANR-18-IDEX-0001, to JAT).
- dc.format.mimetype application/pdf
- dc.identifier.citation He R, Al-Tamimi J, Sánchez-Benavides G, Montaña-Valverde G, Domingo Gispert J, Grau-Rivera O, et al. Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech. Brain Res. 2024 May 1;1830:148806. DOI: 10.1016/j.brainres.2024.148806
- dc.identifier.doi http://dx.doi.org/10.1016/j.brainres.2024.148806
- dc.identifier.issn 0006-8993
- dc.identifier.uri http://hdl.handle.net/10230/60820
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Brain Res. 2024 May 1;1830:148806
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105241GB-I00
- dc.rights © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Aβ amyloid
- dc.subject.keyword Cognitive decline
- dc.subject.keyword Cortical gradient
- dc.subject.keyword Dementia
- dc.subject.keyword Functional connectivity
- dc.title Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion