Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
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- dc.contributor.author Everson, Todd M.
- dc.contributor.author Vives Usano, Marta, 1990-
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Bustamante Pineda, Mariona
- dc.date.accessioned 2021-12-15T07:28:43Z
- dc.date.available 2021-12-15T07:28:43Z
- dc.date.issued 2021
- dc.description.abstract Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
- dc.description.sponsorship This work was supported by the National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223]. It is supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (ZO1 ES49019). And also by the National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223 and the Intramural Research Program of the NIH-NIEHS, ESZ0149019]
- dc.format.mimetype application/pdf
- dc.identifier.citation Everson TM, Vives-Usano M, Seyve E, Cardenas A, Lacasaña M, Craig JM et al. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. Nat Commun. 2021 Aug 24;12(1):5095. DOI: 10.1038/s41467-021-24558-y
- dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-24558-y
- dc.identifier.issn 2041-1723
- dc.identifier.uri http://hdl.handle.net/10230/49209
- dc.language.iso eng
- dc.publisher Nature Research
- dc.rights © Todd M. Everson et al. 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Embarassades -- Consum de tabac
- dc.subject.other Placenta
- dc.subject.other Fetus -- Trastorns del creixement
- dc.title Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion