Validity of the CR-POSSUM model in surgery for colorectal cancer in Spain (CCR-CARESS study) and comparison with other models to predict operative mortality

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  • dc.contributor.author Baré, Marisaca
  • dc.contributor.author Alcantara, Manuel Jesúsca
  • dc.contributor.author Gil, Maria Joséca
  • dc.contributor.author Collera, Pabloca
  • dc.contributor.author Pont, Marinaca
  • dc.contributor.author Escobar, Antonioca
  • dc.contributor.author Sarasqueta, Cristinaca
  • dc.contributor.author Redondo, Maximinoca
  • dc.contributor.author Briones, Eduardoca
  • dc.contributor.author Dujovne, Paulaca
  • dc.contributor.author Quintana, José Maríaca
  • dc.contributor.author CARESS-CCR Study Groupca
  • dc.date.accessioned 2018-10-18T07:26:57Z
  • dc.date.available 2018-10-18T07:26:57Z
  • dc.date.issued 2018
  • dc.description.abstract BACKGROUND: To validate and recalibrate the CR- POSSUM model and compared its discriminatory capacity with other European models such as POSSUM, P-POSSUM, AFC or IRCS to predict operative mortality in surgery for colorectal cancer. METHODS: Prospective multicenter cohort study from 22 hospitals in Spain. We included patients undergoing planned or urgent surgery for primary invasive colorectal cancers between June 2010 and December 2012 (N = 2749). Clinical data were gathered through medical chart review. We validated and recalibrated the predictive models using logistic regression techniques. To calculate the discriminatory power of each model, we estimated the areas under the curve - AUC (95% CI). We also assessed the calibration of the models by applying the Hosmer-Lemeshow test. RESULTS: In-hospital mortality was 1.5% and 30-day mortality, 1.7%. In the validation process, the discriminatory power of the CR-POSSUM for predicting in-hospital mortality was 73.6%. However, in the recalibration process, the AUCs improved slightly: the CR-POSSUM reached 75.5% (95% CI: 67.3-83.7). The discriminatory power of the CR-POSSUM for predicting 30-day mortality was 74.2% (95% CI: 67.1-81.2) after recalibration; among the other models the POSSUM had the greatest discriminatory power, with an AUC of 77.0% (95% CI: 68.9-85.2). The Hosmer-Lemeshow test showed good fit for all the recalibrated models. CONCLUSION:The CR-POSSUM and the other models showed moderate capacity to discriminate the risk of operative mortality in our context, where the actual operative mortality is low. Nevertheless the IRCS might better predict in-hospital mortality, with fewer variables, while the CR-POSSUM could be slightly better for predicting 30-day mortality.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Baré M, Alcantara MJ, Gil MJ, Collera P, Pont M, Escobar A. et al. Validity of the CR-POSSUM model in surgery for colorectal cancer in Spain (CCR-CARESS study) and comparison with other models to predict operative mortality. BMC Health Serv Res. 2018 Jan 29;18(1):49. DOI: 10.1186/s12913-018-2839-x
  • dc.identifier.doi http://dx.doi.org/10.1186/s12913-018-2839-x
  • dc.identifier.issn 1472-6963
  • dc.identifier.uri http://hdl.handle.net/10230/35619
  • dc.language.iso eng
  • dc.publisher BioMed Centralca
  • dc.relation.ispartof BMC Health Services Research. 2018 Jan 29;18(1):49
  • dc.rights Copyright © The Author(s). 2018. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
  • dc.subject.keyword Colorectal cancer
  • dc.subject.keyword Cr-possum
  • dc.subject.keyword Operative mortality
  • dc.subject.keyword Predictive model
  • dc.subject.other Còlon -- Càncer -- Cirurgia
  • dc.title Validity of the CR-POSSUM model in surgery for colorectal cancer in Spain (CCR-CARESS study) and comparison with other models to predict operative mortalityca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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