Reduced plasma orexin-A concentrations are associated with cognitive deficits in anorexia nervosa

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  • dc.contributor.author Steward, Trevor
  • dc.contributor.author Torre Fornell, Rafael de la
  • dc.contributor.author Fernández Aranda, Fernando
  • dc.date.accessioned 2020-04-24T07:16:02Z
  • dc.date.available 2020-04-24T07:16:02Z
  • dc.date.issued 2019
  • dc.description.abstract Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.
  • dc.description.sponsorship We thank CERCA Programme/Generalitat de Catalunya for institutional support. This manuscript and research was supported by grants from the Ministerio de Economía y Competitividad (PSI2015-68701-R), Ministerio de Sanidad, Servicios Sociales e Igualdad (PR338/17), Instituto de Salud Carlos III (ISCIII) (FIS PI14/00290 and PI17/01167) and co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe. CIBERObn and CIBERSAM are both initiatives of ISCIII. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This research was supported by a PNSD (PR338/17-MSSSI) grant. GMB is supported by a predoctoral AGAUR grant (2018 FI_B2 00174), grant co-funded by the European Social Fund (ESF) “ESF”, investing in your future. With the support of the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia. CVA is supported by a predoctoral Grant of the Ministerio de Educación, Cultura y Deporte (FPU16/01453). ABC is funded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Steward T, Mestre-Bach G, Granero R, Sánchez I, Riesco N, Vintró-Alcaraz C, et al. Reduced plasma orexin-A concentrations are associated with cognitive deficits in anorexia nervosa. Sci Rep. 2019 May 27; 9(1):7910. DOI: 10.1038/s41598-019-44450-6
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-44450-6
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/44315
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Scientific Reports. 2019 May 27;9(1):7910
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2015-68701-R
  • dc.rights The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Anorèxia nerviosa
  • dc.title Reduced plasma orexin-A concentrations are associated with cognitive deficits in anorexia nervosa
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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