Sex differences in multimorbidity, inappropriate medication and adverse outcomes of inpatient care: MoPIM cohort study
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Baré, Marisa
- dc.contributor.author Lleal, Marina
- dc.contributor.author Sevilla-Sánchez, Daniel
- dc.contributor.author Ortonobes, Sara
- dc.contributor.author Herranz, Susana
- dc.contributor.author Fernández, Olivia
- dc.contributor.author Corral-Vázquez, Celia
- dc.contributor.author Molist, Núria
- dc.contributor.author Nazco, Gloria Julia
- dc.contributor.author Martín-González, Candelaria
- dc.contributor.author Márquez, Miguel Ángel
- dc.contributor.author MoPIM study group
- dc.date.accessioned 2024-05-02T07:13:45Z
- dc.date.available 2024-05-02T07:13:45Z
- dc.date.issued 2023
- dc.description.abstract There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (≥65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% ≥85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode.
- dc.format.mimetype application/pdf
- dc.identifier.citation Baré M, Lleal M, Sevilla-Sánchez D, Ortonobes S, Herranz S, Ferrandez O, et al. Sex differences in multimorbidity, inappropriate medication and adverse outcomes of inpatient care: MoPIM cohort study. Int J Environ Res Public Health. 2023 Feb 18;20(4):3639. DOI: 10.3390/ijerph20043639
- dc.identifier.doi http://dx.doi.org/10.3390/ijerph20043639
- dc.identifier.issn 1660-4601
- dc.identifier.uri http://hdl.handle.net/10230/59973
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Int J Environ Res Public Health. 2023 Feb 18;20(4):3639
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Sex perspective
- dc.subject.keyword Multimorbidity
- dc.subject.keyword Network analysis
- dc.subject.keyword Potentially inappropriate medication
- dc.subject.keyword Adverse drug reaction
- dc.subject.keyword In-hospital mortality
- dc.subject.keyword Outcomes of care
- dc.title Sex differences in multimorbidity, inappropriate medication and adverse outcomes of inpatient care: MoPIM cohort study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion