To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases

Supek, Fran; Lehner, Ben, 1978-; Lindeboom, Rik G.H.

To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases

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dc.contributor.author Supek, Fran
dc.contributor.author Lehner, Ben, 1978-
dc.contributor.author Lindeboom, Rik G.H.
dc.date.accessioned 2021-03-24T12:52:18Z
dc.date.issued 2020
dc.description.abstract The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs bearing premature termination codons (PTCs). Decades of work have elucidated the molecular mechanisms of NMD. More recently, statistical analyses of large genomic datasets have allowed the importance of known and novel 'rules of NMD' to be tested and combined into methods that accurately predict whether PTC-containing mRNAs are degraded or not. We discuss these genomic approaches and how they can be applied to identify diseases and individuals that may benefit from inhibition or activation of NMD. We also discuss the importance of NMD for gene editing and tumor evolution, and how inhibiting NMD may be an effective strategy to increase the efficacy of cancer immunotherapy.
dc.description.sponsorship This work was funded by the European Research Council (ERC) starting grant HYPER-INSIGHT ( 757700 , to F.S.) and ERC consolidator grant IR-DC ( 616434 to B.L.). F.S. and B.L. are funded by the ICREA Research Professor program. F.S. and B.L. acknowledge support of the Severo Ochoa Centres of Excellence program to the IRB Barcelona and to the CRG, respectively. B.L. and F.S. were supported by the Fondo Europeo de Desarrollo Regional (FEDER)/ Ministerio de Ciencia, Innovación y Universidades - Agencia Estatal de Investigación projects BFU2017-89488-P and RegioMut ( BFU2017-89833-P ), respectively. B.L. was further supported by the Bettencourt Schueller Foundation , the Agencia de Gestio d'Ajuts Universitaris i de Recerca ( 2017 SGR 1322 ), and the Centres de Recerca de Catalunya (CERCA) program/ Generalitat de Catalunya . B.L. also acknowledges the support of the Spanish Ministry of Economy, Industry, and Competitiveness to the European Molecular Biology Laboratory (EMBL) partnership
dc.format.mimetype application/pdf
dc.identifier.citation Supek F, Lehner B, Lindeboom RGK. To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases. Trends Genet. 2020 Dec 2; S0168-9525(20): 30307-3. DOI: 10.1016/j.tig.2020.11.002
dc.identifier.doi http://dx.doi.org/10.1016/j.tig.2020.11.002
dc.identifier.issn 0168-9525
dc.identifier.uri http://hdl.handle.net/10230/46927
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Trends in Genetics 2020 Dec 2;S0168-9525(20):30307-3
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/757700
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/616434
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89488-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89833-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Genètica
dc.subject.other Malalties congènites
dc.subject.other Càncer
dc.subject.other Càncer -- Immunoteràpia
dc.title To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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