Efficient validation strategies in environmental analytical chemistry: A focus on organic micropollutants in water samples

Hernández, Félix; Fabregat-Safont, David; Campos-Mañas, Marina; Quintana, José Benito

doi:http://dx.doi.org/10.1146/annurev-anchem-091222-112115

Efficient validation strategies in environmental analytical chemistry: A focus on organic micropollutants in water samples

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Hernández F, Fabregat-Safont D, Campos-Mañas M, Quintana JB. Efficient validation strategies in environmental analytical chemistry: A focus on organic micropollutants in water samples. Annu Rev Anal Chem (Palo Alto Calif). 2023 Jun 14;16(1):401-28. DOI: 10.1146/annurev-anchem-091222-112115

Abstract

This article critically reviews analytical method validation and quality control applied to the environmental chemistry field. The review focuses on the determination of organic micropollutants (OMPs), specifically emerging contaminants and pesticides, in the aquatic environment. The analytical technique considered is (gas and liquid) chromatography coupled to mass spectrometry (MS), including high-resolution MS for wide-scope screening purposes. An analysis of current research practices outlined in the literature has been performed, and key issues and analytical challenges are identified and critically discussed. It is worth emphasizing the lack of specific guidelines applied to environmental analytical chemistry and the minimal regulation of OMPs in waters, which greatly affect method development and performance, requirements for method validation, and the subsequent application to samples. Finally, a proposal is made for method validation and data reporting, which can be understood as starting points for further discussion with specialists in environmental analytical chemistry.