Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study

Michalopoulou, Eleni; Darker, Iain; Iotti, Valentina; Slonim, Efrat; de Koning, Harry J.; Alcantara Souza, Rodrigo; Burrion, Jean-Benoit; de Montgolfier, Sandrine; Vissac-Sabatier, Cécile; Guindy, Michal; Pattacini, Pierpaolo; Delaloge, Suzette; Gilbert, Fiona J.; Chen, Yan; MyPeBS Consortium

Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study

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dc.contributor.author Michalopoulou, Eleni
dc.contributor.author Darker, Iain
dc.contributor.author Iotti, Valentina
dc.contributor.author Slonim, Efrat
dc.contributor.author de Koning, Harry J.
dc.contributor.author Alcantara Souza, Rodrigo
dc.contributor.author Burrion, Jean-Benoit
dc.contributor.author de Montgolfier, Sandrine
dc.contributor.author Vissac-Sabatier, Cécile
dc.contributor.author Guindy, Michal
dc.contributor.author Pattacini, Pierpaolo
dc.contributor.author Delaloge, Suzette
dc.contributor.author Gilbert, Fiona J.
dc.contributor.author Chen, Yan
dc.contributor.author MyPeBS Consortium
dc.date.accessioned 2025-11-12T18:16:34Z
dc.date.available 2025-11-12T18:16:34Z
dc.date.issued 2025
dc.date.updated 2025-11-12T18:16:34Z
dc.description.abstract Purpose: A survey conducted by the European Society of Breast Imaging (EUSOBI) in 2023 revealed significant variations in Quality Assurance (QA) practices across Europe. The UK encourages regular performance monitoring for screen readers. This study aimed to assess the variability in diagnostic performance among readers participating in a wider prospective randomised trial across multiple countries. Method: In this retrospective multinational study, breast imaging readers from the MyPeBS clinical trial examined a test set of 40 challenging breast screening cases using the PERFORMS software, from March 2021 to February 2022. The challenging set, enriched with biopsy-proven cancers, aimed to differentiate readers by their level of diagnostic performance. Cancer detection and correct return to screen rates were calculated for each participant. Results: A total of 110 readers from 6 countries completed the PERFORMS test set, while 88 also completed an accompanying questionnaire collecting information about their breast screening work and experience. The study revealed variability in cancer detection rates (M = 73.6 %, SD = 19.7 %, range 0.0 %-100.0 %) and correct return to screen rates (M = 79.7 %, SD = 10.5 %, range 46.4 %-100.0 %). Outliers with extremely low cancer detection (2.7 % of participants) and correct return to screen rates (1.8 % of participants) were also identified. Conclusions: Breast imaging readers' performance in test set-based assessments like PERFORMS can reflect real-world screening proficiency. The presence of outlier readers with low diagnostic performance on the test highlights the need for double reading and for standardised QA protocols to ensure patient safety and service efficiency.
dc.description.sponsorship The current study is funded as part of the MyPeBS clinical trial, which is supported by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 755394. The funders had no role in in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication.
dc.format.mimetype application/pdf
dc.identifier.citation Michalopoulou E, Darker I, Iotti V, Slonim E, de Koning HJ, Souza RA, Burrion JB, De Montgolfier S, Vissac-Sabatier C, Guindy M, Pattacini P, Delaloge S, Gilbert FJ, Chen Y; MyPeBS Consortium. Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study. Eur J Radiol. 2025 Feb;183:111938. DOI: 10.1016/j.ejrad.2025.111938
dc.identifier.doi http://dx.doi.org/10.1016/j.ejrad.2025.111938
dc.identifier.issn 0720-048X
dc.identifier.uri http://hdl.handle.net/10230/71873
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof European Journal of Radiology. 2025;183:111938
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/755394
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Cancer detection
dc.subject.keyword Mammography
dc.subject.keyword Performance
dc.subject.keyword Quality assurance
dc.subject.keyword Sensitivity and specificity
dc.title Breast imaging readers' performance in the PERFORMS test-set based assessment scheme within the MyPeBS international randomised study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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