Associations between aldosterone-renin-ratio and bone parameters derived from peripheral quantitative computed tomography and impact microindentation in men

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  • dc.contributor.author Holloway-Kew, Kara L.
  • dc.contributor.author Anderson, Kara B.
  • dc.contributor.author Rufus-Membere, Pamela
  • dc.contributor.author Tembo, Monica C.
  • dc.contributor.author Sui, Sophia X.
  • dc.contributor.author Hyde, Natalie K.
  • dc.contributor.author Kotowicz, Mark A.
  • dc.contributor.author Gwini, Stella M.
  • dc.contributor.author Yang, Jun
  • dc.contributor.author Diez-Perez, Adolfo
  • dc.contributor.author Henneberg, Maciej
  • dc.contributor.author Liao, Wan-Hui
  • dc.contributor.author Pasco, Julie A.
  • dc.date.accessioned 2024-04-26T06:32:46Z
  • dc.date.available 2024-04-26T06:32:46Z
  • dc.date.issued 2023
  • dc.description.abstract Components of the renin-angiotensin-aldosterone system (RAAS) are present on bone cells. One measure of RAAS activity, the aldosterone-renin-ratio (ARR), is used to screen for primary aldosteronism. Associations between ARR and bone mineral density are conflicting. This study investigated associations between ARR and peripheral quantitative computed tomography (pQCT) and impact microindentation (IMI). Male participants (n = 431) were from the Geelong Osteoporosis Study. "Likely" primary aldosteronism was defined as ARR ≥ 70 pmol/mIU. Another group, "possible" primary aldosteronism, was defined as either ARR ≥ 70 pmol/mIU or taking a medication that affects the RAAS, but not a beta blocker, and renin < 15 mU/L. Using pQCT, images at 4% and 66% of radial (n = 365) and tibial (n = 356) length were obtained. Using IMI measurements, bone material strength index (BMSi; n = 332) was determined. Associations between ARR or likely/possible primary aldosteronism and IMI or pQCT-derived bone parameters were tested using median regression. ARR and aldosterone values were not associated with any of the pQCT-derived bone variables in either unadjusted or adjusted analyses. Men with likely primary aldosteronism (n = 16), had lower adjusted total bone area (radial 66% site, - 12.5%). No associations were observed for men with possible primary aldosteronism (unadjusted or adjusted). No associations with BMSi were observed (p > 0.05). There were no associations between ARR or aldosterone and pQCT-derived bone parameters. Men with likely primary aldosteronism had lower bone area, suggesting clinically high levels of ARR may have a negative impact on bone health.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Holloway-Kew KL, Anderson KB, Rufus-Membere P, Tembo MC, Sui SX, Hyde NK, et al. Associations between aldosterone-renin-ratio and bone parameters derived from peripheral quantitative computed tomography and impact microindentation in men. Calcif Tissue Int. 2023 Nov;113(5):496-510. DOI: 10.1007/s00223-023-01131-x
  • dc.identifier.doi http://dx.doi.org/10.1007/s00223-023-01131-x
  • dc.identifier.issn 0171-967X
  • dc.identifier.uri http://hdl.handle.net/10230/59912
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Calcif Tissue Int. 2023 Nov;113(5):496-510
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Aldosterone-renin-ratio
  • dc.subject.keyword Bone material strength index
  • dc.subject.keyword Impact microindentation
  • dc.subject.keyword Males
  • dc.subject.keyword Peripheral quantitative computed tomography
  • dc.subject.keyword Primary aldosteronism
  • dc.title Associations between aldosterone-renin-ratio and bone parameters derived from peripheral quantitative computed tomography and impact microindentation in men
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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