Real-world walking cadence in people with COPD
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- dc.contributor.author Delgado Ortiz, Laura
- dc.contributor.author Balcells Vilarnau, Eva, 1967-
- dc.contributor.author Buekers, Joren
- dc.contributor.author Gimeno Santos, Elena, 1980-
- dc.contributor.author Rodríguez Chiaradia, Diego Agustín
- dc.contributor.author García Aymerich, Judith
- dc.date.accessioned 2024-04-18T05:45:43Z
- dc.date.available 2024-04-18T05:45:43Z
- dc.date.issued 2024
- dc.description.abstract Introduction: The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence. Methods: We assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7 days' accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries. Results: Participants were mostly male (80%) and had mean±sd age of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57±19% predicted and walked 6880±3926 steps·day-1. Mean walking cadence was 88±9 steps·min-1, followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90-0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV1, 6-min walk distance, physical activity (steps·day-1, time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min-1, 95% CI 0.91-0.99, p=0.009). Conclusions: Higher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome.
- dc.description.sponsorship ISGlobal acknowledges support from the grant CEX2018–000806-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Programme.
- dc.format.mimetype application/pdf
- dc.identifier.citation Delgado-Ortiz L, Ranciati S, Arbillaga-Etxarri A, Balcells E, Buekers J, Demeyer H, et al. Real-world walking cadence in people with COPD. ERJ Open Res. 2024 Mar 4;10(2):00673-2023. DOI: 10.1183/23120541.00673-2023
- dc.identifier.doi http://dx.doi.org/10.1183/23120541.00673-2023
- dc.identifier.issn 2312-0541
- dc.identifier.uri http://hdl.handle.net/10230/59815
- dc.language.iso eng
- dc.publisher European Respiratory Society
- dc.relation.ispartof ERJ Open Res. 2024 Mar 4;10(2):00673-2023
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018–000806-S
- dc.rights © The authors 2024. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (http://creativecommons.org/licenses/by-nc/4.0/). For commercial reproduction rights and permissions contact permissions@ersnet.org
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.other Pulmons--Malalties obstructives
- dc.title Real-world walking cadence in people with COPD
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion