Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

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• dc.contributor.author Sentís, Alexis
• dc.contributor.author Martin-Sánchez, Mario
• dc.contributor.author Arando, Maider
• dc.contributor.author Vall, Martí
• dc.contributor.author Barberà, María Jesús
• dc.contributor.author Ocaña, Inma
• dc.contributor.author González Cordón, Ana
• dc.contributor.author Alsina, Mercè
• dc.contributor.author Martin-Ezquerra, Gemma
• dc.contributor.author Knobel Freud, Hernando
• dc.contributor.author Gurguí, Mercè
• dc.contributor.author Vives, Alvaro
• dc.contributor.author Coll, Josep
• dc.contributor.author Caylà i Busqueras, Joan A.
• dc.contributor.author Garcia de Olalla, Patricia
• dc.contributor.author STI-HIV groupo Barcelona
• dc.date.accessioned 2019-11-18T08:31:30Z
• dc.date.available 2019-11-18T08:31:30Z
• dc.date.issued 2019
• dc.description.abstract OBJECTIVES: Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the epidemiological characteristics and trends in the incidence of gonorrhoea, syphilis, HIV and venereal lymphogranuloma (LGV) among 15-24-year-olds in Barcelona, and to determine factors associated with HIV coinfection. DESIGN: We performed a population-based incidence study covering the 2007-2015 period. PARTICIPANTS: All new cases of STI-HIV, gonorrhoea, infectious syphilis and LGV-notified to the epidemiological surveillance system in Barcelona between 2007 and 2015. 1218 cases were studied: 84.6% were men, 19.3% were 15-19 years old and 50.6% were born in Spain. Among men, 73.7% were men who have sex with men (MSM); among women, 85.6% were women that have sex with men. PRIMARY AND SECONDARY OUTCOMES: Incidence of HIV, gonorrhoea, infectious syphilis and LGV. HIV coinfection. RESULTS: There was an increase in the incidence of gonorrhoea, from 1.9 cases per 10 000 people in 2007 to 7.6/10 000 in 2015 (p<0.01), in MSM from 27.1 to 228.8/10 000 (p<0.01). The incidence of syphilis increased from 0.4/10 000 in 2007 to 3.1/10 000 in 2015 (significant in men only, p<0.01), in MSM from 18.1 to 116.9/10 000 (p<0.01). The incidence of HIV showed a non-significant increase in men (p=0.27), and that of LGV remained stable (p=0.59). Factors associated with increased risk of HIV coinfection included being MSM (adjusted OR[ORa]=14.14, 95% CI 3.34 to 59.91) and having >10 sexual partners (ORa=4.11, 95% CI 1.53 to 11.01) or STI diagnosis during the previous 12 months (ORa=2.06; 95% CI 1.13 to 3.77). CONCLUSIONS: The incidence of gonorrhoea and syphilis among 15-24-year-olds increased, while HIV infection remained stable but with a high incidence among MSM. Being MSM, having sex with multiple partners and having a diagnosis of an STI in the previous 12 months were factors associated with HIV coinfection
• dc.format.mimetype application/pdf
• dc.identifier.citation Sentís A, Martin-Sanchez M, Arando M, Vall M, Barbera MJ, Ocaña I et al. Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city. BMJ Open. 2019 May 5;9(5):e027245. DOI: 10.1136/bmjopen-2018-027245
• dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2018-027245
• dc.identifier.issn 2044-6055
• dc.identifier.uri http://hdl.handle.net/10230/42875
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof BMJ Open. 2019 May 5;9(5):e027245
• dc.rights Copyright © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Hiv coinfection
• dc.subject.keyword Adolescents
• dc.subject.keyword Incidence study
• dc.subject.keyword Sexually transmitted infections
• dc.subject.keyword Trends
• dc.subject.keyword Young people
• dc.title Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion