Infertility, IL-17, IL-33 and microbiome cross-talk: The extended ARIA-MeDALL hypothesis
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- dc.contributor.author Hamamah, Samir
- dc.contributor.author Barry, Fatima
- dc.contributor.author Vannier, Sarah
- dc.contributor.author Anahory, Tal
- dc.contributor.author Haahtela, Tari
- dc.contributor.author Antó i Boqué, Josep Maria
- dc.contributor.author Chapron, Charles
- dc.contributor.author Ayoubi, Jean-Marc
- dc.contributor.author Czarlewski, Wienczyslawa
- dc.contributor.author Bousquet, Jean
- dc.date.accessioned 2025-02-12T07:20:35Z
- dc.date.available 2025-02-12T07:20:35Z
- dc.date.issued 2024
- dc.description.abstract Infertility, defined as the inability to obtain pregnancy after 12 months of regular unprotected sexual intercourse, has increased in prevalence over the past decades, similarly to chronic, allergic, autoimmune, or neurodegenerative diseases. A recent ARIA-MeDALL hypothesis has proposed that all these diseases are linked to dysbiosis and to some cytokines such as interleukin 17 (IL-17) and interleukin 33 (IL-33). Our paper suggests that endometriosis, a leading cause of infertility, is linked to endometrial dysbiosis and two key cytokines, IL-17 and IL-33, which interact with intestinal dysbiosis. Intestinal dysbiosis contributes to elevated estrogen levels, a primary factor in endometriosis. Estrogens strongly activate IL-17 and IL-33, supporting the existence of a gut-endometrial axis as a significant contributor to infertility.
- dc.format.mimetype application/pdf
- dc.identifier.citation Hamamah S, Barry F, Vannier S, Anahory T, Haahtela T, Antó JM, et al. Infertility, IL-17, IL-33 and microbiome cross-talk: The extended ARIA-MeDALL hypothesis. Int J Mol Sci. 2024 Nov 7;25(22):11981. DOI: 10.3390/ijms252211981
- dc.identifier.doi http://dx.doi.org/10.3390/ijms252211981
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/69585
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Int J Mol Sci. 2024 Nov 7;25(22):11981
- dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword IL-17
- dc.subject.keyword IL-33
- dc.subject.keyword Dysbiosis
- dc.subject.keyword Endometriosis
- dc.subject.keyword Estrogens
- dc.subject.keyword Infertility
- dc.title Infertility, IL-17, IL-33 and microbiome cross-talk: The extended ARIA-MeDALL hypothesis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion