Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice

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• dc.contributor.author Berrendero Díaz, Fernando, 1971-ca
• dc.contributor.author Kieffer, Brigitte L.ca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.date.accessioned 2012-07-05T06:53:53Z
• dc.date.available 2012-07-05T06:53:53Z
• dc.date.issued 2002ca
• dc.description.abstract The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion and hot-plate tests were reduced in the mutant mice, whereas no difference between genotypes was observed in the locomotor responses. The rewarding effects induced by nicotine were then investigated using the conditioning place-preference paradigm. Nicotine produced rewarding responses in wild-type mice but failed to produce place preference in knock-out mice, indicating the inability of this drug to induce rewarding effects in the absence of μ-opioid receptors. Finally, the somatic expression of the nicotine withdrawal syndrome, precipitated in dependent mice by the injection of mecamylamine, was evaluated. Nicotine withdrawal was significantly attenuated in knock-out mutants when compared with wild-type mice. In summary, the present results show that μ-opioid receptors are involved in the rewarding responses induced by nicotine and participate in its antinociceptive responses and the expression of nicotine physical dependence.
• dc.description.sponsorship This work has been supported by grants from Plan Nacional Sobre Drogas, European Communities BIOM ED2 (98-2227), Human Frontier Science Program Organization (RG0077/2000-B), Generalitat de Catalunya (Research Distinction), and Laboratorios Dr. Esteve
• dc.format.mimetype application/pdfca
• dc.identifier.citation Berrendero, F.; Kieffer, B.L.; Maldonado, R. Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. J. Neurosci. 2002;22(24):10935-40. DOI: 10.1523/JNEUROSCI.22-24-10935.2002ca
• dc.identifier.doi http://dx.doi.org/10.1523/JNEUROSCI.22-24-10935.2002
• dc.identifier.issn 0270-6474ca
• dc.identifier.uri http://hdl.handle.net/10230/16664
• dc.language.iso engca
• dc.publisher Society for Neuroscienceca
• dc.relation.ispartof Journal of Neuroscience. 2002;22(24):10935-40
• dc.rights © 2002, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/22/24/10935ca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Nicotine
• dc.subject.keyword Opioid
• dc.subject.keyword Knock-out mice
• dc.subject.keyword Withdrawal
• dc.subject.keyword Conditioning place preference
• dc.subject.keyword Reward
• dc.subject.other Nicotina -- Addicció
• dc.subject.other Nicotina -- Efectes fisiològics
• dc.subject.other Receptors nicotínics
• dc.title Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out miceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersion