RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12

Salgado, Heladia; Gelpí, Josep Lluís; Collado Vides, Pedro Julio

doi:http://dx.doi.org/10.1093/nar/gkad1072

RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12

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Salgado H, Gama-Castro S, Lara P, Mejia-Almonte C, Alarcón-Carranza G, López-Almazo AG et al. RegulonDB v12.0: a comprehensive resource of transcriptional regulation in E. coli K-12. Nucleic Acids Res. 2024 Jan 5;52(D1):D255-64. DOI: 10.1093/nar/gkad1072

Abstract

RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput methodologies. Here, we describe biological advances since our last NAR paper of 2019. We explain the changes to satisfy FAIR requirements. We also present a full reconstruction of the RegulonDB computational infrastructure, which has significantly improved data storage, retrieval and accessibility and thus supports a more intuitive and user-friendly experience. The integration of graphical tools provides clear visual representations of genetic regulation data, facilitating data interpretation and knowledge integration. RegulonDB version 12.0 can be accessed at https://regulondb.ccg.unam.mx.