Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study

Gómez-Acebo, Inés; Dierssen Sotos, Trinidad; Fernández-Navarro, Pablo; Palazuelos, Camilo; Moreno, Víctor; Aragonés, Núria; Castaño Vinyals, Gemma; Jiménez-Moleón, José Juan; Ruiz-Cerdá, Jose Luis; Pérez-Gómez, Beatriz; Ruiz Dominguez, José Manuel; Alonso Molero, Jessica; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier

Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study

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dc.contributor.author Gómez-Acebo, Inésca
dc.contributor.author Dierssen Sotos, Trinidadca
dc.contributor.author Fernández-Navarro, Pabloca
dc.contributor.author Palazuelos, Camiloca
dc.contributor.author Moreno, Víctorca
dc.contributor.author Aragonés, Núriaca
dc.contributor.author Castaño Vinyals, Gemmaca
dc.contributor.author Jiménez-Moleón, José Juanca
dc.contributor.author Ruiz-Cerdá, Jose Luisca
dc.contributor.author Pérez-Gómez, Beatrizca
dc.contributor.author Ruiz Dominguez, José Manuelca
dc.contributor.author Alonso Molero, Jessicaca
dc.contributor.author Pollan, Marinaca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Llorca, Javierca
dc.date.accessioned 2018-07-25T06:44:41Z
dc.date.available 2018-07-25T06:44:41Z
dc.date.issued 2017
dc.description.abstract Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model.
dc.format.mimetype application/pdf
dc.identifier.citation Gómez-Acebo I, Dierssen-Sotos T, Fernandez-Navarro P, Palazuelos C, Moreno V, Aragonés N et al. Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study. Sci Rep. 2017 Aug 21;7(1):8994. DOI: 10.1038/s41598-017-09386-9
dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-09386-9
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/35258
dc.language.iso eng
dc.publisher Nature Publishing Groupca
dc.relation.ispartof Scientific Reports. 2017 Aug 21;7(1):8994
dc.rights Copyright © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Pròstata -- Càncer
dc.title Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Studyca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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