Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Yu, Jingru
- dc.contributor.author Ploner, Alexander
- dc.contributor.author Kordes, Maximilian
- dc.contributor.author Löhr, J. Matthias
- dc.contributor.author Nilsson, Magnus
- dc.contributor.author López De Maturana, Evangelina
- dc.contributor.author Estudillo, Lidia
- dc.contributor.author Renz, Harald
- dc.contributor.author Carrato, Alfredo
- dc.contributor.author Molero, Xavier
- dc.contributor.author Real, Francisco X.
- dc.contributor.author Malats i Riera, Núria
- dc.contributor.author Ye, Weimin
- dc.date.accessioned 2021-02-19T06:52:06Z
- dc.date.available 2021-02-19T06:52:06Z
- dc.date.issued 2021
- dc.description.abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, Stage I/II, n = 71; advanced PDAC, Stage III/IV, n = 64), 13 benign lesions/chronic pancreatitis patients and 72 healthy individuals, with corresponding plasma samples from a case-control study in Sweden were included. A proximity extension assay was used to detect 92 cancer-related proteins, and an enzyme-linked immunosorbent assay/electrochemiluminescence immunoassay was used to detect CA19-9. Predictive features were selected from these 93 candidate proteins and three covariates in the Swedish participants, and then validated in Spanish participants, including 37 early PDAC patients, 38 advanced PDAC patients, 19 chronic pancreatitis patients and 36 healthy controls. A panel of eight proteins discriminating early PDAC from healthy individuals was identified, and the cross-validated area under the curves (AUCs) were 0.85 (95% confidence interval, 95% CI, 0.78-0.91) and 0.81 (95% CI, 0.70-0.92) in the Swedish and Spanish participants, respectively. Another eight-protein panel was predictive for classifying advanced PDAC from healthy controls in two populations, with cross-validated AUCs of 0.89 (95% CI, 0.83-0.95) and 0.90 (95% CI, 0.83-0.98), respectively. In conclusion, eight protein biomarkers were identified and externally validated, potentially allowing early detection of PDAC patients if validated in additional prospective studies.
- dc.format.mimetype application/pdf
- dc.identifier.citation Yu J, Ploner A, Kordes M, Löhr M, Nilsson M, de Maturana MEL, Estudillo L, Renz H, Carrato A, Molero X, Real FX, Malats N, Ye W. Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma. Int J Cancer. 2021; 148(8):2048-58. DOI: 10.1002/ijc.33464
- dc.identifier.doi http://dx.doi.org/10.1002/ijc.33464
- dc.identifier.issn 0020-7136
- dc.identifier.uri http://hdl.handle.net/10230/46533
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Int J Cancer. 2021; 148(8):2048-58
- dc.rights © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword AUC
- dc.subject.keyword Biomarkers
- dc.subject.keyword Early diagnosis
- dc.subject.keyword Pancreatic ductal adenocarcinoma
- dc.subject.keyword Proteomics
- dc.title Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion