Drosophila dorsal closure: An orchestra of forces to zip shut the embryo
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- dc.contributor.author Hayes, D. Peran, 1983-ca
- dc.contributor.author Solon, Jérômeca
- dc.date.accessioned 2018-06-19T07:53:46Z
- dc.date.available 2018-06-19T07:53:46Z
- dc.date.issued 2017
- dc.description.abstract Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it has been extensively studied in the last twenty years. The process requires the coordination of several force generating mechanisms, that together will zip shut the epidermis. Recent works have provided a precise description of the cellular behavior at the origin of these forces and proposed quantitative models of the process. In this review, we will describe the different forces acting in dorsal closure. We will present our current knowledge on the mechanisms generating and regulating these forces and report on the different quantitative mathematical models proposed so far.
- dc.description.sponsorship The research in the Solon lab is granted by the Spanish Ministry of Economy and Competitiveness, Plan Nacional, BFU2010-16546 and 'Centro de Excelencia Severo Ochoa 2013-2017', SEV-2012-0208 and P.H. has received a fellowship from 'La Caixa' PhD program. We acknowledge the support of the CERCA Programme/Generalitat de Catalunya.
- dc.format.mimetype application/pdf
- dc.identifier.citation Hayes P, Solon J. Drosophila dorsal closure: An orchestra of forces to zip shut the embryo. Mech Dev. 2017 Apr;144(Pt A):2-10. DOI: 10.1016/j.mod.2016.12.005. Epub 2017 Jan 7
- dc.identifier.doi http://dx.doi.org/10.1016/j.mod.2016.12.005
- dc.identifier.issn 0925-4773
- dc.identifier.uri http://hdl.handle.net/10230/34925
- dc.language.iso eng
- dc.publisher Elsevierca
- dc.relation.ispartof Mechanisms of Development. 2017 Apr;144(Pt A):2-10
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2010-16546
- dc.rights © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Dorsal closure
- dc.subject.keyword Embryonic development
- dc.subject.keyword Embryo
- dc.subject.keyword Drosophila proteins
- dc.subject.keyword Drosophila melanogaster
- dc.subject.keyword Body patterning
- dc.title Drosophila dorsal closure: An orchestra of forces to zip shut the embryoca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion