Revisiting the global workspace orchestrating the hierarchical organization of the human brain

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• dc.contributor.author Deco, Gustavo
• dc.contributor.author Vidaurre, Diego
• dc.contributor.author Kringelbach, Morten L.
• dc.date.accessioned 2021-03-10T08:10:13Z
• dc.date.available 2021-03-10T08:10:13Z
• dc.date.issued 2021
• dc.description.abstract A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a ‘global workspace’, but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common ‘functional rich club’. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.
• dc.description.sponsorship The authors thank D. Chicharro, R. Quian Quiroga, A. Brovelli, J.-P.Changeux and S. Dehaene for their insightful comments on the manuscript, as well as A. Horn and N. Li for their help with diffusion MRI. G.D. is supported by a Spanish research project (ref.PID2019-105772GB-I00 AEI FEDER EU) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI) and European Regional Development Funds (FEDER); HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme and SGR Research Support Group support (ref. 2017 SGR 1545), funded by the Catalan Agency for Management of University and Research Grants (AGAUR). M.L.K. is supported by the ERC Consolidator Grant: CAREGIVING (no. 615539), Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript
• dc.format.mimetype application/pdf
• dc.identifier.citation Deco G, Vidaurre D, Kringelbach ML. Revisiting the global workspace orchestrating the hierarchical organization of the human brain. Nat Hum Behav. 2021 Jan 4;5:497–511. DOI: 10.1038/s41562-020-01003-6
• dc.identifier.doi http://dx.doi.org/10.1038/s41562-020-01003-6
• dc.identifier.issn 2397-3374
• dc.identifier.uri http://hdl.handle.net/10230/46716
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nature Human Behavior. 2021 Jan 4;5:497–511
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
• dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/615539
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Brain orchestration
• dc.subject.keyword Neuroscience
• dc.subject.keyword Human brain
• dc.title Revisiting the global workspace orchestrating the hierarchical organization of the human brain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion