Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation.

Peláez García, Alberto; Barderas, Rodrigo; Mendes, Marta; López Lucendo, María; Sanchez, J.C.; García de Herreros, Antonio; Casal, José Ignacio

Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation.

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dc.contributor.author Peláez García, Albertoca
dc.contributor.author Barderas, Rodrigoca
dc.contributor.author Mendes, Martaca
dc.contributor.author López Lucendo, Maríaca
dc.contributor.author Sanchez, J.C.ca
dc.contributor.author García de Herreros, Antonioca
dc.contributor.author Casal, José Ignacioca
dc.date.accessioned 2015-10-20T08:58:42Z
dc.date.available 2015-10-20T08:58:42Z
dc.date.issued 2015
dc.description.abstract The transcription factor (TF) Snail1 is a major inducer of the epithelial-mesenchymal transition (EMT) during embryonic development and cancer progression. Ectopic expression of Snail in murine mesenchymal stem cells (mMSC) abrogated their differentiation to osteoblasts or adipocytes. We used either stable isotopic metabolic labeling (SILAC) for 3T3-L1 cells or isobaric labeling with tandem mass tags (TMT) for mMSC stably transfected cells with Snail1 or control. We carried out a proteomic analysis on the nuclear fraction since Snail is a nuclear TF that mediates its effects mainly through the regulation of other TFs. Proteomics data have been deposited in ProteomeXchange via the PRIDE partner repository with the dataset identifiers PXD001529 and PXD002157 (Vizcaino et al., 2014) [1]. Data are associated with a research article published in Molecular and Cellular Proteomics (Pelaez-Garcia et al., 2015) [2].ca
dc.description.sponsorship Alberto Peláez-García was a recipient of a FPI fellowship. Rodrigo Barderas was supported by the Ramón y Cajal Programme of the Spanish Ministry of Economy and Competitiveness (MINECO). This research was supported by grants to established research groups (AECC), BIO2012-31023 from the Spanish Ministry of Economy and Competitiveness, S2011/BMD-2344/ (Colomics2) from Comunidad de Madrid and Grant PRB2 (IPT13/0001 – ISCIII-SGEFI/FEDER) from ProteoRed-ISCIII.
dc.format.mimetype application/pdfca
dc.identifier.citation Peláez-García A, Barderas R, Mendes M, Lopez-Lucendo M, Sanchez JC, García de Herreros A. et al. Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation. Data Brief. 2015 Jul 31;4:606-13. doi: 10.1016/j.dib.2015.07.027.ca
dc.identifier.doi http://dx.doi.org/10.1016/j.dib.2015.07.027
dc.identifier.issn 2352-3409
dc.identifier.uri http://hdl.handle.net/10230/24860
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Data in Brief. 2015 Jul 31;4:606-13
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-31023
dc.rights c)2015 Peláez-García A, Barderas R, Mendes M, Lopez-Lucendo M, Sanchez JC, García de Herreros A, Casal JI. Published by Elsevier Inc. This is an openaccess article under the CC BY license(http://creativecommons.org/licenses/by/4.0/)ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Cèl·lules mare mesenquimàtiquesca
dc.subject.other Càncerca
dc.title Data from proteomic characterization of the role of Snail1 in murine mesenchymal stem cells and 3T3-L1 fibroblasts differentiation.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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