Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
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- dc.contributor.author Peralta-Garcia, Alejandro
- dc.contributor.author Torrens Fontanals, Mariona
- dc.contributor.author Stepniewski, Tomasz Maciej, 1988-
- dc.contributor.author Grau-Expósito, Judith
- dc.contributor.author Perea, David
- dc.contributor.author Ayinampudi, Vikram
- dc.contributor.author Waldhoer, Maria
- dc.contributor.author Zimmermann, Mirjam
- dc.contributor.author Buzón, María J.
- dc.contributor.author Genescà, Meritxell
- dc.contributor.author Selent, Jana
- dc.date.accessioned 2022-01-28T08:05:51Z
- dc.date.available 2022-01-28T08:05:51Z
- dc.date.issued 2021
- dc.description.abstract Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to identify drug candidates that are able to block the entrance of the virus into human cells. By combining virtual screening with in vitro pseudovirus assays and antiviral assays in Human Lung Tissue (HLT) cells, we identify entrectinib as a potential antiviral drug.
- dc.format.mimetype application/pdf
- dc.identifier.citation Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Expósito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzón MJ, Genescà M, Selent J. Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells. Int J Mol Sci. 2021;22(24):13592. DOI: 10.3390/ijms222413592
- dc.identifier.doi http://dx.doi.org/10.3390/ijms222413592
- dc.identifier.issn 1422-0067
- dc.identifier.uri http://hdl.handle.net/10230/52352
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Int J Mol Sci. 2021;22(24):13592
- dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword COVID-19
- dc.subject.keyword SARS-CoV-2
- dc.subject.keyword Drug repurposing
- dc.subject.keyword Viral cell entry assays
- dc.subject.keyword Virtual screening
- dc.title Entrectinib-A SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion