Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
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- dc.contributor.author McCulloch, Drummond E-Wen
- dc.contributor.author Moos Knudsen, Gitte
- dc.contributor.author Streeter Barrett, Frederick
- dc.contributor.author Doss, Manoj K.
- dc.contributor.author Carhart-Harris, Robin Lester
- dc.contributor.author Rosas, Fernando E.
- dc.contributor.author Deco, Gustavo
- dc.contributor.author Kringelbach, Morten L.
- dc.contributor.author Preller, Katrin H.
- dc.contributor.author Ramaekers, Johannes G.
- dc.contributor.author Mason, Natasha L.
- dc.contributor.author Müller, Felix
- dc.contributor.author MacDonald Fisher, Patrick
- dc.date.accessioned 2023-03-06T07:33:46Z
- dc.date.available 2023-03-06T07:33:46Z
- dc.date.issued 2022
- dc.description.abstract Clinical research into serotonergic psychedelics is expanding rapidly, showing promising efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI) is a commonly used strategy to identify psychedelic-induced changes in neural pathways in clinical and healthy populations. Here we, a large group of psychedelic imaging researchers, review the 42 research articles published to date, based on the 17 unique studies evaluating psychedelic effects on rs-fMRI, focusing on methodological variation. Prominently, we observe that nearly all studies vary in data processing and analysis methodology, two datasets are the foundation of over half of the published literature, and there is lexical ambiguity in common outcome metric terminology. We offer guidelines for future studies that encourage coherence in the field. Psychedelic rs-fMRI will benefit from the development of novel methods that expand our understanding of the brain mechanisms mediating its intriguing effects; yet, this field is at a crossroads where we must also consider the critical importance of consistency and replicability to effectively converge on stable representations of the neural effects of psychedelics.
- dc.format.mimetype application/pdf
- dc.identifier.citation McCulloch DEW, Moos Knudsen G, Streeter Barrett F, Doss MK, Carhart-Harris RL, Rosas FE, Deco G, Kringelbach ML, Preller KH, Ramaekers JG, Mason NL, Müller F, MacDonald Fisher P. Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses. Neurosci Biobehav Rev. 2022;138:104689. DOI: 10.1016/j.neubiorev.2022.104689
- dc.identifier.doi http://dx.doi.org/10.1016/j.neubiorev.2022.104689
- dc.identifier.issn 0149-7634
- dc.identifier.uri http://hdl.handle.net/10230/56059
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Neuroscience & Biobehavioral Reviews. 2022;138:104689.
- dc.rights © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Resting-state
- dc.subject.keyword Psychedelic
- dc.subject.keyword Entheogen
- dc.subject.keyword Hallucinogen
- dc.subject.keyword Replication
- dc.subject.keyword Neuroimaging
- dc.subject.keyword FMRI
- dc.subject.keyword Serotonin
- dc.subject.keyword Human
- dc.subject.keyword Clinical
- dc.subject.keyword DMT
- dc.subject.keyword Psilocybin
- dc.subject.keyword Psilocin
- dc.title Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion