Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD
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- dc.contributor.author Tang, Jun
- dc.contributor.author Ramis Cabrer, Daniel, 1993-
- dc.contributor.author Curull Serrano, Víctor
- dc.contributor.author Wang, Xuejie
- dc.contributor.author Qin, Liyun
- dc.contributor.author Mateu Jiménez, Mercè, 1990-
- dc.contributor.author Duran Jordà, Xavier, 1974-
- dc.contributor.author Pijuan Andujar, Lara
- dc.contributor.author Rodríguez-Fuster, Alberto
- dc.contributor.author Aguiló Espases, Rafael
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2020-09-18T07:13:17Z
- dc.date.available 2020-09-18T07:13:17Z
- dc.date.issued 2020
- dc.description.abstract Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), natural killer (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD. Methods: Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients. Results: Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma. Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker. Conclusions: Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types.
- dc.format.mimetype application/pdf
- dc.identifier.citation Tang J, Ramis-Cabrer D, Curull V, Wang X, Qin L, Mateu-Jiménez M. et al. Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD. Cancers (Basel). 2020 May 13; 12(5):1217. DOI: 10.3390/cancers12051217
- dc.identifier.doi http://dx.doi.org/10.3390/cancers12051217
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/45314
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cancers (Basel). 2020 May 13;12(5):1217
- dc.rights © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword COPD
- dc.subject.keyword IL-10 and interferon-gamma
- dc.subject.keyword T regulatory cells
- dc.subject.keyword Immune tumor microenvironment
- dc.subject.keyword Lung cancer
- dc.subject.keyword Natural killer cells
- dc.subject.keyword Immunoglobulin-secreting plasma cells
- dc.title Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion