The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms

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  • dc.contributor.author Benito, Natividad
  • dc.contributor.author Sorli Redó, M. Luisa
  • dc.contributor.author Horcajada Gallego, Juan Pablo
  • dc.date.accessioned 2020-02-10T08:22:16Z
  • dc.date.available 2020-02-10T08:22:16Z
  • dc.date.issued 2019
  • dc.description.abstract The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Benito N, Mur I, Ribera A, Soriano A, Rodríguez-Pardo D, Sorlí L,et al. The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms. J Clin Med. 2019 May 13;8(5):673. DOI: 10.3390/jcm8050
  • dc.identifier.doi http://dx.doi.org/10.3390/jcm8050
  • dc.identifier.issn 2077-0383
  • dc.identifier.uri http://hdl.handle.net/10230/43530
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Antimicrobial empirical treatment
  • dc.subject.keyword Classification schemes for prosthetic joint infections
  • dc.subject.keyword Microbial etiology
  • dc.subject.keyword Multidrug-resistant organisms
  • dc.subject.keyword Prosthetic joint infection
  • dc.title The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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