Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Llauradó Cabot, Gemma
- dc.contributor.author Cano, Albert
- dc.contributor.author Albert, Lara
- dc.contributor.author Ballesta, Silvia
- dc.contributor.author Mazarico, Isabel
- dc.contributor.author Luchtenberg, María-Florencia
- dc.contributor.author González Sastre, Montserrat
- dc.contributor.author Megia, Ana
- dc.contributor.author Simó, Rafael
- dc.contributor.author Vendrell, Joan
- dc.contributor.author González Clemente, José Miguel
- dc.date.accessioned 2020-03-27T07:22:28Z
- dc.date.available 2020-03-27T07:22:28Z
- dc.date.issued 2019
- dc.description.abstract Objectives: Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for this population. We aimed to assess the relationship between the Steno Type 1 Risk Engine (ST1RE) and arterial stiffness (AS), and to identify potential cut-off points of interest in clinical practice. Design and methods: A total of 179 patients with T1DM (50.8% men, mean age 41.2±13.1 years), without established cardiovascular disease, were evaluated for clinical and anthropometric data (including classical cardiovascular risk factors), and AS measured by aortic pulse-wave velocity (aPWV). The ST1RE was used to estimate 10-year cardiovascular risk and patients were classified into 3 groups: low- (<10%; n = 105), moderate- (10-20%; n = 53) and high-risk (≥20%; n = 21). Results: When compared with the low- and moderate-risk groups, patients in the high-risk group were older, had higher prevalence of hypertension, dyslipidemia and insulin-resistance, and had higher body-mass index and HbA1c. aPWV increased in parallel with estimated cardiovascular risk (6.4±1.0, 8.4±1.3 and 10.3±2.6m/s; p<0.001). As an evaluation of model performance, the C-statistic of aPWV was 0.914 (95% confidence interval [CI]:0.873-0.950) for predicting moderate/high-risk and 0.879 (95%CI:0.809-0.948) for high-risk, according to the ST1RE. The best cut-off points of aPWV were 7.3m/s (sensitivity:86%, specificity:83%) and 8.7m/s (sensitivity:76%, specificity:86%) for moderate/high- and high-risk, respectively. Conclusions: AS is highly correlated with the scores obtained from the ST1RE. We have identified two cut-off points of AS that can clearly discriminate moderate/high- and high-risk T1DM patients, which could be of great value in clinical practice.
- dc.format.mimetype application/pdf
- dc.identifier.citation Llauradó G, Cano A, Albert L, Ballesta S, Mazarico I, Luchtenberg MF, et al. Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM. PLoS One. 2019 Sep 4; 14(9):e0220206. DOI: 10.1371/journal.pone.0220206
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0220206
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/44058
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.rights © 2019 Llauradó et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Marcadors bioquímics
- dc.subject.other Diabetis
- dc.title Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion