Genetic variants associated with colorectal adenoma susceptibility

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  • dc.contributor.author Abulí, Annaca
  • dc.contributor.author Castells, Antonica
  • dc.contributor.author Bujanda, Luisca
  • dc.contributor.author Lozano, Juan Joséca
  • dc.contributor.author Bessa Caserras, Xavierca
  • dc.contributor.author Hernández Rodríguez, Cristinaca
  • dc.contributor.author Alvarez Urturi, Cristinaca
  • dc.contributor.author Pellisé, Mariaca
  • dc.contributor.author Esteban Jurado, Claraca
  • dc.contributor.author Hijona, Elizabethca
  • dc.contributor.author Buron Pust, Andreaca
  • dc.contributor.author Macià Guilà, Francesc Assísca
  • dc.contributor.author Grau, Jaumeca
  • dc.contributor.author Guayta, Rafaelca
  • dc.contributor.author Castellví Bel, Sergica
  • dc.contributor.author Andreu García, Montserratca
  • dc.contributor.author PROCOLON research groupca
  • dc.date.accessioned 2016-06-20T10:34:16Z
  • dc.date.available 2016-06-20T10:34:16Z
  • dc.date.issued 2016
  • dc.description.abstract BACKGROUND: Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM: To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS: We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. RESULTS: We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. CONCLUSIONS: Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.ca
  • dc.description.sponsorship This work was supported by grants from: Instituto de Salud Carlos III-FEDER (RD09/0076/00036), the Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC), Fondo de Investigación Sanitaria/FEDER (PI10/00918, PI11/00219, PI14/00173, PI14/00441), Ministerio de Economía y Competitividad (SAF2010-19273), Asociación Española contra el Cáncer (Fundación Científica GCB13131592CAST), and COST Action BM1206 (SCB). SCB is supported by a contract from the Fondo de Investigación Sanitaria (CP 03-0070) and Agència de Gestió d'Ajuts i de Recerca (Generalitat de Catalunya, 2014SGR255, 2014SGR135). CIBERehd is funded by the Instituto de Salud Carlos III.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Abulí A, Castells A, Bujanda L, Lozano JJ, Bessa X, Hernández C. et al. Genetic variants associated with colorectal adenoma susceptibility. PloS One. 2016 Apr 14;11(4):e0153084. DOI: 10.1371/journal.pone.0153084ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0153084
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/26947
  • dc.language.iso spaca
  • dc.publisher Public Library of Scienceca
  • dc.relation.ispartof PloS One. 2016 Apr 14;11(4):e0153084
  • dc.rights © 2016 Abulí et al. This is an openaccess article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Còlon -- Càncer -- Aspectes genèticsca
  • dc.title Genetic variants associated with colorectal adenoma susceptibilityca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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