Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial

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• dc.contributor.author Toledo, Estefania
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.date.accessioned 2024-03-12T07:22:27Z
• dc.date.available 2024-03-12T07:22:27Z
• dc.date.issued 2023
• dc.description.abstract The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidence of AF. We conducted a nested case-control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention.Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16-1.51; p < 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF.Current Controlled Trials number, ISRCTN35739639.
• dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was supported by the National Institutes of Health grants R01HL118264 and R01DK102896. The PREDIMED trial (Prevención con Dieta Mediterránea) was supported by the official funding agency for biomedical research of the Spanish government, the Instituto de Salud Carlos III, through the grant coordinated by MAMG for a research network specifically developed during 2006-2013 for the trial (RTIC RD 06/0045) and a previous grant coordinated by RE (RTIC G03/140) during 2003-2005 and through the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición and by grants from: the Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007); the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (PI04–2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505, and PI13/00462); the Ministerio de Ciencia e Investigación (AGL-2009–13906-C02 and AGL2010–22319-C03); the Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007); the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010–181, GVACOMP2011–151, CS2010-AP-111, and CS2011-AP-042); the Regional Government of Navarra (P27/2011); and the European Union in the frame of the Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’ to the Fatty Acid Metabolism—Interlinking Diet with Cardiometabolic Health (FAME)-consortium (01EA1704). J. Salas-Salvadó, gratefully acknowledges the financial support by ICREA under the ICREA Academia programme. C. Wittenbecher was supported by an individual fellowship from the German Research Foundation (DFG).
• dc.format.mimetype application/pdf
• dc.identifier.citation Toledo E, Wittenbecher C, Razquin C, Ruiz-Canela M, Clish CB, Liang L et al. Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial. J Physiol Biochem. 2023 May;79(2):355-4. DOI: 10.1007/s13105-023-00958-0
• dc.identifier.doi http://dx.doi.org/10.1007/s13105-023-00958-0
• dc.identifier.issn 1138-7548
• dc.identifier.uri http://hdl.handle.net/10230/59374
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof J Physiol Biochem. 2023 May;79(2):355-4
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009–13906-C02
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010–22319-C03
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Atrial fibrillation
• dc.subject.keyword Dietary intervention
• dc.subject.keyword Lipidomics
• dc.subject.keyword Metabolomics
• dc.subject.keyword Nested case–control study
• dc.title Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion