Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia

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• dc.contributor.author Badia, Josep M.
• dc.contributor.author Flores-Yelamos, Miriam
• dc.contributor.author Vázquez, Ana
• dc.contributor.author Arroyo-García, Nares
• dc.contributor.author Puig-Asensio, Mireia
• dc.contributor.author Parés, David
• dc.contributor.author Pera Roman, Miguel
• dc.contributor.author López Contreras, Joaquín
• dc.contributor.author Limón, Enric
• dc.contributor.author Pujol, Miquel
• dc.contributor.author Colorectal Surveillance Team
• dc.date.accessioned 2022-09-08T06:32:07Z
• dc.date.available 2022-09-08T06:32:07Z
• dc.date.issued 2021
• dc.description.abstract Background: the role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery.
• dc.format.mimetype application/pdf
• dc.identifier.citation Badia JM, Flores-Yelamos M, Vázquez A, Arroyo-García N, Puig-Asensio M, Parés D, et al. Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia. J Clin Med. 2021 Nov 29; 10(23): 5636. DOI: 10.3390/jcm10235636
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10235636
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/54024
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2021 by Badia JM, Flores-Yelamos M, Vázquez A, Arroyo-García N, Puig-Asensio M, Parés D. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Colorectal surgery
• dc.subject.keyword Mechanical bowel preparation
• dc.subject.keyword Oral antibiotic prophylaxis
• dc.subject.keyword Preventative measures
• dc.subject.keyword Surgical site infection
• dc.subject.keyword Surgical wound infection
• dc.title Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion