Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation

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• dc.contributor.author Giménez Mínguez, Paulaca
• dc.contributor.author Bijnens, Bartca
• dc.contributor.author Bernardino Perez, Gabrielca
• dc.contributor.author Lluch Álvarez, Èricca
• dc.contributor.author Soveral, Irisca
• dc.contributor.author Gómez, Olgaca
• dc.contributor.author García Cañadilla, Patricia, 1985-ca
• dc.date.accessioned 2017-09-06T14:03:54Z
• dc.date.available 2017-09-06T14:03:54Z
• dc.date.issued 2017
• dc.description Comunicació presentada a: the 9th International Conference Functional Imaging and Modelling of the Heart FIMH 2017, celebrat de l'11 al 13 de juny de 2017 a Toronto, Canadà.ca
• dc.description.abstract Aortic coarctation is one of the most difficult cardiac defects to diagnose before birth, and it accounts for 8% of congenital heart diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to decrease the risk of morbidity and mortality; however the fetal hemodynamic changes are not fully understood and current imaging methods are limited to accurately diagnosis this congenital defect. Objective: We propose to use a lumped model of the fetal circulation to provide insights into the hemodynamic changes in fetuses with aortic coarctation, and thus helping to improve its diagnosis. Methods: To achieve this goal a patient-specific lumped model of the fetal circulation was implemented in OpenCOR, including the modeling of different types and degrees of aortic coarctation. A parametric study of degree and type of coarctation was performed, where blood flow distribution, cerebroplacental ratio, pressure drop over the coarctation and left ventricular pressure were quantified. Results: Obvious changes in the fetal hemodynamics were observed only from 80% of coarctation, corresponding to the clinically used cutoff for pressure drop of 20 mmHg. Furthermore, the observed hemodynamic changes were different depending on the location and degree of the coarctation.en
• dc.description.sponsorship This study was partially supported by the Spanish Ministry of Economy and Competitiveness (grant TIN2014-52923-R; Maria de Maeztu Units of Excellence Programme - MDM-2015-0502), FEDER and the European Union Horizon 2020 Programme for Research and Innovation, under grant agreement No. 642676 (CardioFunXion).
• dc.format.mimetype application/pdf
• dc.identifier.citation Giménez Mínguez P, Bijnens B, Bernardino G, Lluch E, Soveral I, Gómez O, Garcia-Canadilla P. Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation. In: Pop M, Wright GA, editors. Functional Imaging and Modelling of the Heart. 9th International Conference, FIMH 2017, Proceedings. 2017 Jun 11-13; Toronto, Canada. p. 471-80. (LNCS; no. 10263). DOI: 10.1007/978-3-319-59448-4_45
• dc.identifier.doi http://dx.doi.org/10.1007/978-3-319-59448-4_45
• dc.identifier.issn 0302-9743
• dc.identifier.uri http://hdl.handle.net/10230/32752
• dc.language.iso eng
• dc.publisher Springerca
• dc.relation.ispartof Pop M, Wright GA, editors. Functional Imaging and Modelling of the Heart. 9th International Conference, FIMH 2017, Proceedings. 2017 Jun 11-13; Toronto, Canada. p. 471-80. (LNCS; no. 10263).
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642676
• dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-59448-4_45
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Fetal circulationen
• dc.subject.keyword Modelingen
• dc.subject.keyword Aortic coarctationen
• dc.title Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulationca
• dc.type info:eu-repo/semantics/conferenceObject
• dc.type.version info:eu-repo/semantics/acceptedVersion