Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation
Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation
Citació
- Giménez Mínguez P, Bijnens B, Bernardino G, Lluch E, Soveral I, Gómez O, Garcia-Canadilla P. Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation. In: Pop M, Wright GA, editors. Functional Imaging and Modelling of the Heart. 9th International Conference, FIMH 2017, Proceedings. 2017 Jun 11-13; Toronto, Canada. p. 471-80. (LNCS; no. 10263). DOI: 10.1007/978-3-319-59448-4_45
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Descripció
Resum
Aortic coarctation is one of the most difficult cardiac defects to diagnose before birth, and it accounts for 8% of congenital heart diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to decrease the risk of morbidity and mortality; however the fetal hemodynamic changes are not fully understood and current imaging methods are limited to accurately diagnosis this congenital defect. Objective: We propose to use a lumped model of the fetal circulation to provide insights into the hemodynamic changes in fetuses with aortic coarctation, and thus helping to improve its diagnosis. Methods: To achieve this goal a patient-specific lumped model of the fetal circulation was implemented in OpenCOR, including the modeling of different types and degrees of aortic coarctation. A parametric study of degree and type of coarctation was performed, where blood flow distribution, cerebroplacental ratio, pressure drop over the coarctation and left ventricular pressure were quantified. Results: Obvious changes in the fetal hemodynamics were observed only from 80% of coarctation, corresponding to the clinically used cutoff for pressure drop of 20 mmHg. Furthermore, the observed hemodynamic changes were different depending on the location and degree of the coarctation.Descripció
Comunicació presentada a: the 9th International Conference Functional Imaging and Modelling of the Heart FIMH 2017, celebrat de l'11 al 13 de juny de 2017 a Toronto, Canadà.