Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation

Giménez Mínguez, Paula; Bijnens, Bart; Bernardino Perez, Gabriel; Lluch Álvarez, Èric; Soveral, Iris; Gómez, Olga; García Cañadilla, Patricia, 1985-

doi:http://dx.doi.org/10.1007/978-3-319-59448-4_45

Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation

Citation

Giménez Mínguez P, Bijnens B, Bernardino G, Lluch E, Soveral I, Gómez O, Garcia-Canadilla P. Assessment of haemodynamic remodeling in fetal aortic coarctation using a lumped model of the circulation. In: Pop M, Wright GA, editors. Functional Imaging and Modelling of the Heart. 9th International Conference, FIMH 2017, Proceedings. 2017 Jun 11-13; Toronto, Canada. p. 471-80. (LNCS; no. 10263). DOI: 10.1007/978-3-319-59448-4_45

Abstract

Aortic coarctation is one of the most difficult cardiac defects to diagnose before birth, and it accounts for 8% of congenital heart diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to decrease the risk of morbidity and mortality; however the fetal hemodynamic changes are not fully understood and current imaging methods are limited to accurately diagnosis this congenital defect. Objective: We propose to use a lumped model of the fetal circulation to provide insights into the hemodynamic changes in fetuses with aortic coarctation, and thus helping to improve its diagnosis. Methods: To achieve this goal a patient-specific lumped model of the fetal circulation was implemented in OpenCOR, including the modeling of different types and degrees of aortic coarctation. A parametric study of degree and type of coarctation was performed, where blood flow distribution, cerebroplacental ratio, pressure drop over the coarctation and left ventricular pressure were quantified. Results: Obvious changes in the fetal hemodynamics were observed only from 80% of coarctation, corresponding to the clinically used cutoff for pressure drop of 20 mmHg. Furthermore, the observed hemodynamic changes were different depending on the location and degree of the coarctation.

Description

Comunicació presentada a: the 9th International Conference Functional Imaging and Modelling of the Heart FIMH 2017, celebrat de l'11 al 13 de juny de 2017 a Toronto, Canadà.