Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups

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• dc.contributor.author Mañé, Laura
• dc.contributor.author Flores-Le-Roux, Juana Antonia
• dc.contributor.author Gómez, Nàdia
• dc.contributor.author Chillarón Jordan, Juan José
• dc.contributor.author Llauradó Cabot, Gemma
• dc.contributor.author Gortazar, Lucía
• dc.contributor.author Payà Panadés, Antonio
• dc.contributor.author Pedro-Botet, Juan Carlos
• dc.contributor.author Benaiges Foix, David
• dc.date.accessioned 2019-12-04T09:37:18Z
• dc.date.issued 2019
• dc.description.abstract Aim: To determine, in a multi-ethnic cohort, the association of first-trimester HbA1c levels with the development of pregnancy complications. Methods: A prospective study between April 2013-October 2016. Participants were stratified in five ethnic groups. Women had an HbA1c measurement added to their first antenatal bloods. Primary outcome was macrosomia and secondary outcomes included preeclampsia and large-for-gestational age (LGA). A multivariate logistic regression analysis was performed to adjust for potential confounders in determining the association between different HbA1c cut-off points and obstetric outcomes on each ethnic group. Results: 1,882 pregnancies were included. Analysis was limited to the three main ethnic groups: Caucasian (54.3%), South-Central Asian (19%) and Latin-American (12.2%). There was no association between HbA1c levels and obstetric outcomes among Caucasians. In Latin-Americans, an HbA1c ≥ 5.8% (40 mmol/mol) was associated with higher risk of macrosomia, whereas an HbA1c ≥ 5.9% (41 mmol/mol) was associated with LGA. In South-Central Asian, an HbA1c ≥ 5.7% (39 mmol/mol) was associated with increased risk of macrosomia and a continuous graded relationship between HbA1c levels and preeclampsia and LGA was detected starting at HbA1c levels of 5.4% (36 mmol/mol). Conclusion: First-trimester HbA1c levels perform as a suitable predictor of pregnancy complications in South-Central Asian and Latin-American women whereas in Caucasian no significant associations were found.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mañé L, Flores-Le Roux JA, Gómez N, Chillarón JJ, Llauradó G, Gortazar L. et al. Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups. Diabetes Res Clin Pract. 2019 Apr;150:202-210. DOI 10.1016/j.diabres.2019.03.01
• dc.identifier.doi http://dx.doi.org/10.1016/j.diabres.2019.03.01
• dc.identifier.issn 0168-8227
• dc.identifier.uri http://hdl.handle.net/10230/43085
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.diabres.2019.03.01
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Ethnicity
• dc.subject.keyword Glycosylated haemoglobin
• dc.subject.keyword Large-for-gestational age
• dc.subject.keyword Macrosomia
• dc.subject.keyword Preeclampsia
• dc.subject.keyword Pregnancy outcome
• dc.title Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion