Injectable sensors based on passive rectification of volume-conducted currents

Malik, Shahid; Castellví Fernández, Quim; Becerra Fajardo, Laura; Tudela Pi, Marc; García Moreno, Aracelys; Shojaei Baghini, Maryam; Ivorra Cano, Antoni, 1974-

doi:http://dx.doi.org/10.1109/TBCAS.2020.3002326

Injectable sensors based on passive rectification of volume-conducted currents

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Malik S, Castellví Q, Becerra-Fajardo L, Tudela-Pi M, García-Moreno A, Shojaei Baghini M, Ivorra A. Injectable sensors based on passive rectification of volume-conducted currents. IEEE Trans Biomed Circuits Syst. 2020 Jun 15;14(4):867-78. DOI: 10.1109/TBCAS.2020.3002326

Abstract

Sensing implants that can be deployed by catheterization or by injection are preferable over implants requiring invasive surgery. However, present powering methods for active implants and present interrogation methods for passive implants require bulky parts within the implants that hinder the development of such minimally invasive devices. In this article, we propose a novel approach that potentially enables the development of passive sensing systems overcoming the limitations of previous implantable sensing systems in terms of miniaturization. In this approach implants are shaped as thread-like devices suitable for implantation by injection. Their basic structure consists of a thin elongated body with two electrodes at opposite ends and a simple and small circuit made up of a diode, a capacitor and a resistor. The interrogation method to obtain measurements from the implants consists in applying innocuous bursts of high frequency (≥1 MHz) alternating current that reach the implants by volume conduction and in capturing and processing the voltage signals that the implants produce after the bursts. As proof-of-concept, and for illustrating how to put in practice this novel approach, here we describe the development and characterization of a system for measuring the conductivity of tissues surrounding the implant. We also describe the implementation and the in vitro validation of a 0.95 mm-thick, flexible injectable implant made of off-the-shelf components. For conductivities ranging from about 0.2 to 0.8 S/m, when compared to a commercial conductivity meter, the accuracy of the implemented system was about ±10%.