Lipidomic signature of stroke recurrence after transient ischemic attack

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• dc.contributor.author Purroy, Francisco
• dc.contributor.author Ois Santiago, Angel Javier
• dc.contributor.author Jové, Mariona
• dc.contributor.author Arque, Gloria
• dc.contributor.author Sol, Joaquim
• dc.contributor.author Mauri Capdevila, Gerard
• dc.contributor.author Rodríguez-Campello, Ana
• dc.contributor.author Pamplona, Reinald
• dc.contributor.author Portero Otín, Manuel
• dc.contributor.author Roquer, Jaume
• dc.date.accessioned 2024-05-31T06:14:38Z
• dc.date.available 2024-05-31T06:14:38Z
• dc.date.issued 2023
• dc.description.abstract While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.
• dc.description.sponsorship This study was supported by the Government of Catalonia-Agència de Gestió d'Ajuts Universitaris i de Recerca (FP: 2017SGR1628 and 2021SGR01479; RP: 2021SGR00990); Instituto de Salud Carlos III and co-funded by European Union (ERDF/ESF, "Investing in your future" and "A way to build Europe") (FP: PI17-01725, PI14/01574; M.P-O: PI 17-00134, 20-0155); the Spanish Ministry of Science, Innovation and Universities (RP: RTI2018-099200-B-I00 and PID2022-143140OB-I00); the Department of Health (RP: SLT002/16/00250); and the INVICTUS plus Research Network (Carlos III Health Institute) (FP, CT and GA: RD16-0019-0017; TS: RD16-0019-0012; AO and JR: RD16-0019-0012; AC: RD16-0019-0006. M.J. is a professor under the Serra Hunter program (Generalitat de Catalunya).
• dc.format.mimetype application/pdf
• dc.identifier.citation Purroy F, Ois A, Jove M, Arque G, Sol J, Mauri-Capdevila G, et al. Lipidomic signature of stroke recurrence after transient ischemic attack. Sci Rep. 2023 Aug 22;13(1):13706. DOI: 10.1038/s41598-023-40838-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-023-40838-7
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/60296
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Sci Rep. 2023 Aug 22;13(1):13706
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-099200-B-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-143140OB-I00
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Diseases
• dc.subject.keyword Medical research
• dc.subject.keyword Neurology
• dc.subject.keyword Neuroscience
• dc.subject.keyword Risk factors
• dc.title Lipidomic signature of stroke recurrence after transient ischemic attack
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion